Minireviews
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World J Virol. Mar 25, 2023; 12(2): 100-108
Published online Mar 25, 2023. doi: 10.5501/wjv.v12.i2.100
Immune-mediated liver injury following COVID-19 vaccination
Georgios Schinas, Eleni Polyzou, Vasiliki Dimakopoulou, Stamatia Tsoupra, Charalambos Gogos, Karolina Akinosoglou
Georgios Schinas, Department of Medicine, University of Patras, Patras 26504, Greece
Eleni Polyzou, Vasiliki Dimakopoulou, Stamatia Tsoupra, Charalambos Gogos, Karolina Akinosoglou, Department of Internal Medicine, University of Patras, Patras 26504, Greece
Author contributions: Akinosoglou K and Gogos C conceived the idea; Schinas G performed the literature search, reviewed data, and wrote the manuscript; Polyzou E, Dimakopoulou V, and Tsoupra S performed the literature search and reviewed data; Akinosoglou K and Gogos C critically corrected the manuscript; Akinosoglou K revised the manuscript
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Karolina Akinosoglou, MD, PhD, Associate Professor, Department of Internal Medicine, University of Patras, 5th floor, University General Hospital of Patras, Patras 26504, Greece. akin@upatras.gr
Received: October 11, 2022
Peer-review started: October 11, 2022
First decision: November 15, 2022
Revised: November 23, 2022
Accepted: January 23, 2023
Article in press: January 23, 2023
Published online: March 25, 2023
Processing time: 160 Days and 9.8 Hours
Core Tip

Core Tip: Following the worldwide implementation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination protocols, several reports suggest an increase in the occurrence of autoimmune phenomena involving the liver. Studies on vaccine-induced liver injury point to a specific pattern of hepatocellular injury that involves immune-mediated pathways. This minireview explores the underlying pathophysiology of immune-mediated liver injury following SARS-CoV-2 vaccination and examines the most widely distributed vaccine formulations’ autoimmune and hepatotoxic potential.