Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Sep 25, 2021; 10(5): 229-255
Published online Sep 25, 2021. doi: 10.5501/wjv.v10.i5.229
Oncolytic virus therapy in cancer: A current review
Jonathan Santos Apolonio, Vinícius Lima de Souza Gonçalves, Maria Luísa Cordeiro Santos, Marcel Silva Luz, João Victor Silva Souza, Samuel Luca Rocha Pinheiro, Wedja Rafaela de Souza, Matheus Sande Loureiro, Fabrício Freire de Melo
Jonathan Santos Apolonio, Maria Luísa Cordeiro Santos, Marcel Silva Luz, Samuel Luca Rocha Pinheiro, Wedja Rafaela de Souza, Matheus Sande Loureiro, Fabrício Freire de Melo, Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde, Vitória da Conquista 45029-094, Bahia, Brazil
Vinícius Lima de Souza Gonçalves, João Victor Silva Souza, Universidade Estadual do Sudoeste da Bahia, Campus Vitória da Conquista, Vitória da Conquista 45083-900, Bahia, Brazil
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: Authors declare there are no conflicts of interests in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fabrício Freire de Melo, PhD, Professor, Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Bahia, Brazil. freiremelo@yahoo.com.br
Received: March 10, 2021
Peer-review started: March 10, 2021
First decision: May 5, 2021
Revised: May 19, 2021
Accepted: August 9, 2021
Article in press: August 9, 2021
Published online: September 25, 2021
Processing time: 189 Days and 11.6 Hours
Core Tip

Core Tip: Oncolytic viruses are organisms able to infect and lyse the tumor cells beyond stimulating the immune system to combat the disease. The clinical use of oncolytic viruses has shown to have positive results in the treatment of some types of cancers, contributing to reducing the tumor. Furthermore, the combined use of these viruses and other antitumor therapies have contributed to better prognosis in the patient’s clinical condition.