Passos DF, Schetinger MRC, Leal DB. Purinergic signaling and human immunodeficiency virus/acquired immune deficiency syndrome: From viral entry to therapy. World J Virology 2015; 4(3): 285-294 [PMID: 26279989 DOI: 10.5501/wjv.v4.i3.285]
Corresponding Author of This Article
Daniela BR Leal, PhD, Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, Santa Maria, RS 97105-900, Brazil. daniela.leal@ufsm.br
Research Domain of This Article
Virology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Virology. Aug 12, 2015; 4(3): 285-294 Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.285
Purinergic signaling and human immunodeficiency virus/acquired immune deficiency syndrome: From viral entry to therapy
Daniela F Passos, Maria Rosa C Schetinger, Daniela BR Leal
Daniela F Passos, Daniela BR Leal, Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil
Maria Rosa C Schetinger, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil
Author contributions: Passos DF, Schetinger MRC and Leal DBR solely contributed to this paper.
Conflict-of-interest statement: We declare that we have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Daniela BR Leal, PhD, Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, Santa Maria, RS 97105-900, Brazil. daniela.leal@ufsm.br
Telephone: + 55-55-32209581 Fax: + 55-55-32208242
Received: October 29, 2014 Peer-review started: October 29, 2014 First decision: December 12, 2014 Revised: July 21, 2015 Accepted: August 4, 2015 Article in press: August 7, 2015 Published online: August 12, 2015 Processing time: 288 Days and 5.5 Hours
Abstract
Human immunodeficiency virus (HIV) infection is a serious condition associated to severe immune dysfunction and immunodeficiency. Mechanisms involved in HIV-associated immune activation, inflammation and loss of CD4+ T cells have been extensively studied, including those concerning purinergic signaling pathways. Purinergic signaling components are involved in viral entry and replication and disease progression. Research involving the participation of purinergic signaling in HIV infection has been not only important to elucidate disease mechanisms but also to introduce new approaches to therapy. The involvement of purinergic signaling in the pathogenesis of HIV infection and its implications in the control of the HIV infection are reviewed in this paper.
Core tip: This paper reviews the latest findings regarding the involvement of the purinergic signaling system and human immunodeficiency virus (HIV) infection. On the last 10 years, several studies have been published on the participation of purinergic signaling in HIV infection. The findings helped to elucidate disease mechanisms and proposed new targets and approaches to therapy. We have found that basic and clinical research on this field are very promising and must be further pursued.
