Latchana N, Peck JR, Whitson BA, Henry ML, Elkhammas EA, Black SM. Preservation solutions used during abdominal transplantation: Current status and outcomes. World J Transplant 2015; 5(4): 154-164 [PMID: 26722644 DOI: 10.5500/wjt.v5.i4.154]
Corresponding Author of This Article
Sylvester M Black, MD, PhD, Assistant Professor of Surgery, Department of Surgery, Division of Transplantation, the Ohio State University Wexner Medical Center, 395 W 12th Avenue, Columbus, OH 43210, United States. sylvester.black@osumc.edu
Research Domain of This Article
Transplantation
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Dec 24, 2015; 5(4): 154-164 Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.154
Preservation solutions used during abdominal transplantation: Current status and outcomes
Nicholas Latchana, Joshua R Peck, Bryan A Whitson, Mitchell L Henry, Elmahdi A Elkhammas, Sylvester M Black
Nicholas Latchana, Department of Surgery, the Ohio State University Wexner Medical, Columbus, OH 43210, United States
Joshua R Peck, Department of Internal Medicine, Division of Gastroenterology, the Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Bryan A Whitson, Department of Surgery, Division of Cardiac Surgery, the Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Mitchell L Henry, Elmahdi A Elkhammas, Sylvester M Black, Department of Surgery, Division of Transplantation, the Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Author contributions: Latchana N and Peck JR drafted, reviewed, and revised the manuscript; Whitson BA, Henry ML and Elkhammas EA reviewed and edited the manuscript; Black SM conceptualized, reviewed and edited the manuscript.
Conflict-of-interest statement: All authors declare that they not have any competing commercial, personal, political, intellectual or religious interests in relation to the submitted work.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sylvester M Black, MD, PhD, Assistant Professor of Surgery, Department of Surgery, Division of Transplantation, the Ohio State University Wexner Medical Center, 395 W 12th Avenue, Columbus, OH 43210, United States. sylvester.black@osumc.edu
Telephone: +1-614-2938545 Fax: +1-614-2934541
Received: June 29, 2015 Peer-review started: July 2, 2015 First decision: August 4, 2015 Revised: October 15, 2015 Accepted: November 10, 2015 Article in press: November 11, 2015 Published online: December 24, 2015 Processing time: 177 Days and 1.2 Hours
Core Tip
Core tip: Preservation of abdominal organs during transplant remains an important factor in patient and graft survival. Considerable variation exists between institutions with respect to the preservation solution of choice with an uncertain impact on patient and graft survival. Herein, pertinent clinical studies were reviewed to highlight the best available evidence in the selection of preservation solutions for abdominal transplantation. Histidine-tryptophan-ketoglutarate (HTK) may improve the incidence of biliary complications in hepatic transplants while minimizing costs for renal transplants. However, the use of HTK is dissuaded in pancreas transplants in favor of University of Wisconsin and Celsior solutions given the potential for graft thrombosis with HTK.
