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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Mar 18, 2026; 16(1): 111064
Published online Mar 18, 2026. doi: 10.5500/wjt.v16.i1.111064
Published online Mar 18, 2026. doi: 10.5500/wjt.v16.i1.111064
Simultaneous kidney and pancreas transplantation: Current trends and challenges
Kawther F Alquadan, Amer A Belal, Rohan Mehta, Muhannad Leghrouz, Hisham Ibrahim, Alfonso H Santos, Division of Nephrology, Hypertension & Renal Transplantation, University of Florida, Gainesville, FL 32610, United States
Georgios Vrakas, Department of Surgery, University of Florida, Gainesville, FL 32610, United States
Co-first authors: Kawther F Alquadan and Amer A Belal.
Author contributions: Alquadan K contributed to the conception and design of the work, leading the writing of the original draft, literature review, critical revision and editing, and approval of the final version of the manuscript; Belal AA contributed to the writing of the original draft, literature review, critical revision and editing, and approval of the final version of the manuscript; Mehta RV, Leghrouz M, Ibrahim I, and Vrakas G contributed revision, editing and approval of final version of the manuscript; Santos AH contributed to the conception and design of the work, literature review, critical revisions and editing, and approval of the final version of the manuscript.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alfonso H Santos, Division of Nephrology, Hypertension & Renal Transplantation, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, United States. alfonso.santos@medicine.ufl.edu
Received: June 23, 2025
Revised: July 29, 2025
Accepted: October 24, 2025
Published online: March 18, 2026
Processing time: 206 Days and 14.4 Hours
Revised: July 29, 2025
Accepted: October 24, 2025
Published online: March 18, 2026
Processing time: 206 Days and 14.4 Hours
Core Tip
Core Tip: Pancreas transplantation offers select patients with diabetes significant survival benefits alongside improvement in cardiovascular and metabolic complications. These benefits are most pronounced in patients receiving pancreas transplants as part of simultaneous kidney-pancreas transplants; however, pancreas transplants alone or pancreas after kidney transplants are also available. These surgeries carry certain risks and challenges, both medical and logistical, that have contributed to the recent decline in pancreas transplantation.