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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 18, 2025; 15(4): 106380
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.106380
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.106380
Clinical characteristics and outcomes of keratoplasty in moderate to severe infective corneal ulcers
Lukman Edwar, Dicky Budiman, Ratna Sitompul, Made Susiyanti, Rina La Distia Nora, Yulia Aziza, Ramadhiana Maktazula Tuasikal, Gabriella Hafidha Badruddin, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia
Author contributions: Edwar L participated in the conception and design of the study, acquisition, analysis, and interpretation of the data, and served as the first and corresponding author; Budiman D and Sitompul R contributed to the study design, and data analysis and interpretation; Susiyanti M, Nora RL, and Aziza Y were involved in the data acquisition, collection and interpretation; Tuasikal RM and Badruddin GH participated in the verification and manuscript preparation; All authors critically reviewed and approved the final version of the manuscript and were responsible for the decision to submit the manuscript for publication.
Institutional review board statement: The Ethics Committee of the Faculty of Medicine, University of Indonesia had carefully reviewed (Ethical number: 1302/UN2.F1/ETIK/PPM.00.02/2020) and approved our research protocol on November 2, 2020.
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lukman Edwar, MD, Associate Professor, Department of Opht
Received: February 25, 2025
Revised: March 29, 2025
Accepted: April 24, 2025
Published online: December 18, 2025
Processing time: 268 Days and 2.3 Hours
Revised: March 29, 2025
Accepted: April 24, 2025
Published online: December 18, 2025
Processing time: 268 Days and 2.3 Hours
Core Tip
Core Tip: Corneal ulcers represent a significant cause of visual impairment in Indonesia, commonly following ocular trauma. This study highlights that therapeutic and tectonic keratoplasty effectively preserves eyeball integrity in moderate to severe infective corneal ulcers. Despite a notable improvement in visual acuity, complications such as secondary glaucoma and graft failure are prevalent, emphasizing the need for vigilant post-operative management.