Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 18, 2025; 15(4): 104589
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.104589
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.104589
Early liver transplant for alcohol-associated liver disease: Current state and future directions
Jonathan Jung, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, United States
Bima J Hasjim, Department of Surgery, University of California, Irvine Medical Center, Irvine, CA 92697, United States
Adrienne Chen, Vinayak Rohan, Daniela P Ladner, Department of Surgery, Northwestern University, Chicago, IL 60611, United States
Filza Hussain, Department of Psychiatry, Stanford University, Stanford, CA 94301, United States
Amanda Cheung, Department of Gastroenterology and Hepatology, Northwestern University, Chicago, IL 60611, United States
Co-first authors: Jonathan Jung and Bima J Hasjim.
Author contributions: Cheung A, Vinayak R, and Ladner DP were responsible for conceptualization and design; Jung J, Hasjim BJ, Chen A, and Hussain F were responsible for data collection and analysis of results; Jung J was responsible for original draft manuscript preparation; Hasjim BJ, Vinayak R, Hussain F, and Cheung A reviewing and editing manuscript; all authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Amanda Cheung, MD, Assistant Professor, Department of Gastro
Received: December 25, 2024
Revised: March 17, 2025
Accepted: April 22, 2025
Published online: December 18, 2025
Processing time: 329 Days and 12.8 Hours
Revised: March 17, 2025
Accepted: April 22, 2025
Published online: December 18, 2025
Processing time: 329 Days and 12.8 Hours
Core Tip
Core Tip: Liver transplantation (LT) for alcohol-associated liver disease continues to be an evolving field. As transplant centers internationally continue to increase rates of transplantation for patients with limited sobriety including alcohol-associated hepatitis, there is an ongoing need to standardize the selection process. This appraisal aims to succinctly review the current state of early LT and anticipate future direction for the field.