Expanding role of antibodies in kidney transplantation

doi:10.5500/wjt.v15.i1.99220

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Mar 18, 2025 (publication date) through Dec 3, 2024

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Mar 18, 2025; 15(1): 99220
Published online Mar 18, 2025. doi: 10.5500/wjt.v15.i1.99220

Expanding role of antibodies in kidney transplantation

Khawar Abbas, Muhammed Mubarak

Khawar Abbas, Department of Transplant Immunology, Sindh Institute of Urology & Transplantation, Karachi 74200, Sindh, Pakistan

Muhammed Mubarak, Javed I. Kazi Department of Histopathology, Sindh Institute of Urology & Transplantation, Karachi 74200, Sindh, Pakistan

Author contributions: Abbas K and Mubarak M contributed equally to the conception and study design. All authors performed relevant research, participated in primary and final drafting, and read and approved the final manuscript.

Conflict-of-interest statement: No conflict of interest to declare.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Khawar Abbas, FCPS, MBBS, Professor, Department of Transplant Immunology, Sindh Institute of Urology & Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drkhawar_imuno@yahoo.com

Received: July 17, 2024
Revised: October 21, 2024
Accepted: November 7, 2024
Published online: March 18, 2025
Processing time: 133 Days and 3.8 Hours

Core Tip

Core Tip: Antibodies are of crucial importance in kidney transplantation (KT), posing challenges such as antibody-mediated rejection (AMR) but also offering opportunities for better transplant outcomes through advanced detection, prevention, and treatment strategies. This review explores the role of antibodies in rejection, progress in desensitization, AMR treatments, and their potential to enhance graft survival, reflecting evolving strategies to manage and leverage antibodies in KT.