Expanding role of antibodies in kidney transplantation

Abstract

The role of antibodies in kidney transplant (KT) has evolved significantly over the past few decades. This role of antibodies in KT is multifaceted, encompassing both the challenges they pose in terms of antibody-mediated rejection (AMR) and the opportunities for improving transplant outcomes through better detection, prevention, and treatment strategies. As our understanding of the immunological mechanisms continues to evolve, so too will the approaches to managing and harnessing the power of antibodies in KT, ultimately leading to improved patient and graft survival. This narrative review explores the multifaceted roles of antibodies in KT, including their involvement in rejection mechanisms, advancements in desensitization protocols, AMR treatments, and their potential role in monitoring and improving graft survival.

Keywords: Antibodies; Humoral theory; Kidney transplantation; Rejection

Core Tip: Antibodies are of crucial importance in kidney transplantation (KT), posing challenges such as antibody-mediated rejection (AMR) but also offering opportunities for better transplant outcomes through advanced detection, prevention, and treatment strategies. This review explores the role of antibodies in rejection, progress in desensitization, AMR treatments, and their potential to enhance graft survival, reflecting evolving strategies to manage and leverage antibodies in KT.