Abbas K, Mubarak M. Expanding role of antibodies in kidney transplantation. World J Transplant 2025; 15(1): 99220 [DOI: 10.5500/wjt.v15.i1.99220]
Corresponding Author of This Article
Khawar Abbas, FCPS, MBBS, Professor, Department of Transplant Immunology, Sindh Institute of Urology & Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drkhawar_imuno@yahoo.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Mar 18, 2025; 15(1): 99220 Published online Mar 18, 2025. doi: 10.5500/wjt.v15.i1.99220
Expanding role of antibodies in kidney transplantation
Khawar Abbas, Muhammed Mubarak
Khawar Abbas, Department of Transplant Immunology, Sindh Institute of Urology & Transplantation, Karachi 74200, Sindh, Pakistan
Muhammed Mubarak, Javed I. Kazi Department of Histopathology, Sindh Institute of Urology & Transplantation, Karachi 74200, Sindh, Pakistan
Author contributions: Abbas K and Mubarak M contributed equally to the conception and study design. All authors performed relevant research, participated in primary and final drafting, and read and approved the final manuscript.
Conflict-of-interest statement: No conflict of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Khawar Abbas, FCPS, MBBS, Professor, Department of Transplant Immunology, Sindh Institute of Urology & Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drkhawar_imuno@yahoo.com
Received: July 17, 2024 Revised: October 21, 2024 Accepted: November 7, 2024 Published online: March 18, 2025 Processing time: 133 Days and 3.8 Hours
Abstract
The role of antibodies in kidney transplant (KT) has evolved significantly over the past few decades. This role of antibodies in KT is multifaceted, encompassing both the challenges they pose in terms of antibody-mediated rejection (AMR) and the opportunities for improving transplant outcomes through better detection, prevention, and treatment strategies. As our understanding of the immunological mechanisms continues to evolve, so too will the approaches to managing and harnessing the power of antibodies in KT, ultimately leading to improved patient and graft survival. This narrative review explores the multifaceted roles of antibodies in KT, including their involvement in rejection mechanisms, advancements in desensitization protocols, AMR treatments, and their potential role in monitoring and improving graft survival.
Core Tip: Antibodies are of crucial importance in kidney transplantation (KT), posing challenges such as antibody-mediated rejection (AMR) but also offering opportunities for better transplant outcomes through advanced detection, prevention, and treatment strategies. This review explores the role of antibodies in rejection, progress in desensitization, AMR treatments, and their potential to enhance graft survival, reflecting evolving strategies to manage and leverage antibodies in KT.
