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Review
Copyright: ©Author(s) 2026.
World J Psychiatry. May 19, 2026; 16(5): 116452
Published online May 19, 2026. doi: 10.5498/wjp.v16.i5.116452
Table 1 Commonly used antipsychotic medications
Typical antipsychotics (first-generation)
Atypical antipsychotics (second-generation)
Phenothiazines: Chlorpromazine, fluphenazine, mesoridazine, perphenazine, thioridazine, trifluoperazineAtypical agents: Aripiprazole, clozapine, olanzapine, quetiapine, risperidone, ziprasidone
Butyrophenones: Haloperidol
Others: Loxapine, molindone, thiothixene
Table 2 Prognostic indicators in schizophrenia
Favorable prognostic indicators
Unfavorable prognostic indicators
Female sexMale sex
Being marriedBeing single, divorced, or living alone
Acute onsetInsidious onset
Later age of onsetEarly age of onset
Family history of mood disorderFamily history of schizophrenia
Good premorbid social adjustmentPremorbid schizoid or schizotypal personality
Living in a rural areaLiving in an urban environment
Higher intelligence levelLower intelligence level
Few and brief exacerbationsFrequent or prolonged hospitalizations
Early initiation and regular adherence to treatmentIrregular or absent treatment adherence
Absence of comorbid psychiatric disordersPresence of comorbid psychiatric conditions
Strong family collaboration with the treatment teamDysfunctional family environment or high expressed emotion


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