Correlation of mild cognitive impairment with locomotive syndrome in geriatric cancer patients: A cross-sectional study

Table 1 Univariate analysis of factors influencing locomotive syndrome occurrence

Variables	Classification	n	LS (n)	χ2	P value
Gender	Male	217	73	6.901	0.029
	Female	250	105
Age	60-69	189	32	23.987	< 0.001
	70-79	200	87
	≥ 80	78	59
Marital status	With partner	407	143	2.101	0.432
	Without partner	60	35
Level of education	Illiterate	68	42	2.221	0.484
	Elementary school	89	44
	Junior high school	104	34
	Vocational high school and senior high school	152	37
	University and junior college	54	21
Occupation before retirement	Peasant	135	68	18.819	0.013
	Laborer/clerical worker	263	89
	Personnel of government agencies or public institutions	60	18
	Others	9	3
Monthly income (yuan)	< 2000	152	67	2.623	0.472
	2000-4000	179	71
	> 4000	136	40
Smoking	Yes	76	22	6.434	0.030
	No	391	156
Drinking alcohol	Yes	97	33	1.741	0.813
	No	370	145
Residential situation	Living alone	60	35	1.843	0.721
	Living with family	407	143
Number of chronic diseases combined	0	114	22	28.275	< 0.001
	1	191	71
	2	109	45
	≥ 3	53	40
BMI (kg/m2)	< 18.5	20	18	2.128	0.343
	18.5-23.9	226	162
	≥ 24	221	176
MCI	Yes	143	117	21.321	< 0.001
	No	324	154

LS: Locomotive syndrome; BMI: Body mass index; MCI: Mild cognitive impairment.

Table 2 Logistic regression analysis of factors affecting locomotive syndrome in geriatric cancer patients

Variables	β	SE	Wald χ2	P value	OR	95%CI
Constant	-1.412	0.287	23.324	< 0.001	-	-
MCI (none as reference)	0.521	0.254	7.542	0.017	1.732	1.154-2.708
Age (60-69 as reference)
70-79	1.421	0.203	47.612	< 0.001	3.732	2.543-5.613
≥ 80	2.621	0.312	69.876	< 0.001	9.984	5.675-16.987
Comorbid chronic diseases (0 as reference)
1	0.412	0.321	4.521	< 0.022	1.325	1.023-2.435
2	1.253	0.237	18.224	< 0.001	3.231	2.050-4.453
≥ 3	2.451	0.501	28.487	< 0.001	6.459	4.254-9.023

CI: Confidence interval; OR: Odds ratio; MCI: Mild cognitive impairment.

Table 3 Univariate analysis of factors influencing mild cognitive impairment occurrence

Variables	Classification	n	MCI (n)	χ2	P value
Gender	Male	217	34	9.872	0.019
	Female	250	61
Age	60-69	189	15	23.598	< 0.001
	70-79	200	39
	≥ 80	78	40
Marital status	With partner	407	77	7.098	0.013
	Without partner	60	18
Level of education	Illiterate	68	19	10.346	0.011
	Elementary school	89	23
	Junior high school	104	19
	Vocational high school and senior high school	152	24
	University and junior college	54	10
Occupation before retirement	Peasant	135	26	12.503	0.003
	Laborer/clerical worker	263	59
	Personnel of government agencies or public institutions	60	8
	Others	9	1
Monthly income (yuan)	< 2000	152	30	5.412	0.381
	2000-4000	179	38
	> 4000	136	27
Smoking	Yes	76	16	2.342	0.644
	No	391	89
Drinking alcohol	Yes	97	22	3.189	0.452
	No	370	73
Residential situation	Living alone	60	12	2.137	0.755
	Living with family	407	83
Number of chronic diseases	0	114	17	23.465	< 0.001
	1	191	30
	2	109	25
	≥ 3	53	23
BMI	< 18.5	20	3	3.556	0.382
	18.5-23.9	226	43
	≥ 24	221	49
LS	Yes	271	117	19.989	< 0.001
	No	196	26

LS: Locomotive syndrome; BMI: Body mass index; MCI: Mild cognitive impairment.

Table 4 Logistic regression analysis of factors influencing mild cognitive impairment in geriatric cancer patients

Variables	β	SE	Wald χ2	P value	OR	95%CI
Constant	-2.345	0.349	99.512	< 0.001	0.889	-
LS (none as reference)	0.682	0.212	18.213	< 0.001	2.321	1.489-3.132
Gender (none as reference)	0.4632	0.182	16.678	0.036	1.112	1.028-2.218
Age (60-69 as reference)
70-79	1.122	0.219	18.736	< 0.001	2.879	1.768-4.546
≥ 80	2.512	0.302	54.254	< 0.001	10.865	8.285-15.301
Comorbid chronic diseases (0 as reference)
1	-0.89	0.324	0.189	0.702	1.013	0.672-1.857
2	0.254	0.261	0.817	0.256	1.315	0.662-2.212
≥ 3	0.876	0.342	7.984	0.005	2.876	1.543-4.523

CI: Confidence interval; OR: Odds ratio.

Table 5 Correlation analysis between mild cognitive impairment and locomotive syndrome

GLFS-25	Orientation	Memory	Attention and calculation	Recall	Language	MMSE
r	-0.512	-0.212	-0.422	-0.312	-0.359	-0.436
P value	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001

GLFS: Geriatric Locomotive Function Scale; MMSE: Mini Mental State Examination.