Correlation of mild cognitive impairment with locomotive syndrome in geriatric cancer patients: A cross-sectional study

doi:10.5498/wjp.v16.i4.114148

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World Journal of Psychiatry

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World J Psychiatry. Apr 19, 2026; 16(4): 114148
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.114148

Correlation of mild cognitive impairment with locomotive syndrome in geriatric cancer patients: A cross-sectional study

Ying Chen, Wen-Jing Xu, Hui Lu, Jing Wang, Ling Li, Hui Su, Dan-Hua Liang, Yu-Qing Zhou, Yong-Ping Xu, Jing-Fang Xia, Hui Yu, Yu-Ling Yang

Ying Chen, Hui Lu, Jing Wang, Ling Li, Hui Su, Dan-Hua Liang, Yu-Qing Zhou, Yong-Ping Xu, Jing-Fang Xia, Hui Yu, Yu-Ling Yang, Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu Province, China

Wen-Jing Xu, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu Province, China

Co-first authors: Ying Chen and Wen-Jing Xu.

Author contributions: Chen Y, Xu WJ, Lu H, and Yang YL designed the research study; Chen Y and Xu W contributed equally to this article, they are the co-first authors of this manuscript; Lu H, Wang J, Li L, Liang DH, and Zhou YQ performed the research; Xu YP and Xia JF contributed new reagents and analytic tools; Su H, Yu H, Chen Y, and Yang YL analyzed the data and wrote the manuscript; and all authors have read and approve the final manuscript.

Supported by the Jiangsu Provincial Traditional Chinese Medicine Science and Technology Development Plan Project, No. MS2024063; Scientific and Technological Achievements Promotion Project of Wuxi Municipal Health Commission Project Program, No. T202336; Research Project on Hospital Management Innovation in Jiangsu Province, No. JSYGY-3-2024-601; the Regional Medical Center Development Program under the partnership between Jiangnan University Affiliated Hospital and Donghai County People’s Hospital, No. DHBFH202501 and No. DHBFH202503; and the Wuxi Institute of Translational Medicine Project Program, No. LCYJ202336.

Institutional review board statement: This study was approved by the Medical Ethics Committee of the Affiliated Hospital of Jiangnan University, approval No. LS2023101.

Informed consent statement: Informed consent was obtained from all subjects involved in the study. Written informed consent has been obtained from the patients to publish this paper.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.

Data sharing statement: The datasets used during the current study are available from the corresponding author on reasonable request.

Corresponding author: Yu-Ling Yang, PhD, Department of Oncology, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Wuxi 214122, Jiangsu Province, China. yulingzxc@163.com

Received: September 15, 2025
Revised: November 9, 2025
Accepted: January 9, 2026
Published online: April 19, 2026
Processing time: 199 Days and 1.7 Hours

Abstract

BACKGROUND

Locomotive syndrome (LS), a criterion capable of evaluating physical function at an earlier stage, has been less studied in relation to mild cognitive impairment (MCI). Clarifying the correlation between LS status and MCI in geriatric cancer patients may aid in identifying early risks for cognitive and motor impairments, providing new insights into maintaining patient independence.

AIM

To explore risk factors and the correlation between MCI and LS in geriatric cancer patients.

METHODS

A total of 467 geriatric cancer patients admitted to our hospital from July 2024 to June 2025 were enrolled. MCI was assessed using the Mini Mental State Examination, while locomotive function was evaluated using the Geriatric Locomotive Function Scale-25. Univariate analysis was conducted to evaluate differences in MCI and LS among geriatric cancer patients with different clinical characteristics. Logistic regression was performed to identify independent risk factors. Spearman correlation analysis was employed to assess the relationship between MCI and LS.

RESULTS

The prevalence of LS was 58.0%, and that of MCI was 30.5%. Logistic regression analysis indicated that age, number of chronic comorbidities, educational level, and MCI were independent risk factors for LS. Age, number of chronic comorbidities, and LS were risk factors for MCI. Spearman correlation analysis revealed a negative correlation between Geriatric Locomotive Function Scale-25 and Mini Mental State Examination scores (r = -0.436, P < 0.001).

CONCLUSION

A significant correlation exists between MCI and LS in geriatric cancer patients. Clinical management and nursing care should concurrently address cognitive impairment and LS to improve patients’ overall quality of life and prognosis.

Keywords: Geriatric cancer patients; Locomotive syndrome; Cognitive impairment; Musculoskeletal function; Correlation

Core Tip: Locomotive syndrome (LS), a criterion capable of evaluating physical function at an earlier stage, has been less studied in relation to mild cognitive impairment (MCI). Clarifying the correlation between LS status and MCI in geriatric cancer patients may aid in identifying early risks for cognitive and motor impairments, providing new insights into maintaining patient independence. Therefore, this study aimed to explore influencing factors and correlations between MCI and LS in geriatric cancer patients. Identifying these factors may facilitate targeted interventions, thus improving overall health status and prognosis among geriatric cancer patients.