Correlation of frontal lobe electroencephalogram asymmetry and cognitive prognosis in schizophrenia

doi:10.5498/wjp.v16.i2.111799

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Feb 19, 2026 (publication date) through Feb 2, 2026

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Feb 19, 2026; 16(2): 111799
Published online Feb 19, 2026. doi: 10.5498/wjp.v16.i2.111799

Table 1 Comparison of demographic characteristics between two groups

	Good cognitive prognosis group (n = 52)	Poor cognitive prognosis group (n = 52)	t/χ²	P value
Age (years)	38.56 ± 4.96	37.97 ± 4.68	0.624	0.5341
Female/male	29	27	0.155	0.694
Body mass index (kg/m²)	21.86 ± 2.65	21.93 ± 2.34	0.161	0.873
Years of education (years)	13.86 ± 1.42	13.75 ± 1.53	0.398	0.691
Smoking history (yes/no)	16	18	0.175	0.676
Drinking history (yes/no)	15	17	0.181	0.671
Complication
Hypertension (yes/no)	12	11	0.056	0.813
Diabetes (yes/no)	4	5	0.000	1.000
Depression (yes/no)	14	15	0.048	0.827
Marital status (married/unmarried)	28	24	0.615	0.433
Ethnicity (Han/other)	47	45	0.377	0.539
Course of disease	5.27 ± 1.52	5.23 ± 1.49	0.133	0.894
Pathogeny			0.253	0.969
Family genetic history	9	11
Psychological factor	21	20
Environmental factor	18	17
Internal factors	4	4
Clinical scale score before treatment
Positive symptom score	17.18 ± 2.65	17.97 ± 2.81	1.475	0.1433
Negative symptom score	19.71 ± 1.93	20.32 ± 1.85	1.645	0.103
General pathological symptom evaluation	36.36 ± 7.06	37.65 ± 7.82	0.883	0.3793

Full Size Table

Table 2 Comparison of bilateral frontoparietal networks connectivity and laterality index between two groups

	Good cognitive prognosis group (n = 52)	Poor cognitive prognosis group (n = 52)	t	P value
Left FPN¹	14.32 ± 2.94	12.71 ± 3.47	2.554	0.012
Right FPN²	12.81 ± 2.68	11.28 ± 3.31	2.602	0.011
LI of FPN³	0.06 ± 0.01	0.06 ± 0.02	1413.500	0.685

¹Mean connectivity of left frontoparietal network.

²Mean connectivity of right frontoparietal network.

³Laterality index of mean connectivity of bilateral frontoparietal networks.

FPN: Frontoparietal network; LI: Laterality index.

Full Size Table

Table 3 Correlation analysis between frontal lobe electroencephalography asymmetry and poor cognitive function prognosis in schizophrenia patients

	rho	P value
Eyes-open F4-F3	-0.203	0.039
Eyes-open F6-F5	-0.244	0.013
Eyes-open F2-F1	0.203	0.039
Left FPN¹	-0.239	0.015
Right FPN²	-0.258	0.008

¹Mean connectivity of left frontoparietal network.

²Mean connectivity of right frontoparietal network.

FPN: Frontoparietal network.

Full Size Table

Citation: Sang S, Wang F. Correlation of frontal lobe electroencephalogram asymmetry and cognitive prognosis in schizophrenia. World J Psychiatry 2026; 16(2): 111799
URL: https://www.wjgnet.com/2220-3206/full/v16/i2/111799.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i2.111799