Construction and validation of a personalized prediction model for postpartum anxiety in pregnant women with preeclampsia

Table 1 Comparison of baseline data of pregnant women with preeclampsia, n (%)

Variable	Postpartum anxiety (n = 126)	No postpartum anxiety (n = 356)	t/χ2	P value
Age (mean ± SD)	31.80 ± 3.99	32.04 ± 4.09	0.491	0.624
Degree of education			1.853	0.396
Junior high school and below	31 (24.60)	70 (19.66)
Senior high school (technical secondary school)	61 (48.41)	172 (48.31)
College (higher vocational) or above	34 (26.98)	114 (32.02)
Occupation			5.433	0.143
Unemployed	25 (19.84)	50 (14.04)
Workers and peasants	43 (34.13)	150 (42.13)
Public official	19 (15.08)	37 (10.39)
Other	39 (30.95)	119 (33.43)
Per capita monthly household income			4.491	0.106
< 2500 RMB yuan	22 (17.46)	68 (19.10)
2500-5000 RMB yuan	65 (51.59)	146 (41.01)
> 5000 RMB yuan	39 (30.95)	142 (39.89)
Spousal occupation			3.390	0.335
Unemployed	13 (10.32)	20 (5.62)
Workers and peasants	59 (46.83)	181 (50.83)
Public official	21 (16.67)	57 (16.01)
Other	33 (26.19)	98 (27.53)
Education level of spouse			3.994	0.136
Junior high school and below	19 (15.08)	40 (11.24)
Senior high school (technical secondary school)	58 (46.03)	200 (56.18)
College (higher vocational) or above	49 (38.89)	116 (32.58)
Marital relationship			37.665	< 0.001
Good	39 (30.95)	223 (62.64)
Bad	87 (69.05)	133 (37.36)
Whether it was a planned pregnancy			1.338	0.247
Yes	80 (63.49)	246 (69.10)
No	46 (36.51)	110 (30.90)
Have any experience raising children			0.253	0.615
Yes	38 (30.16)	99 (27.81)
No	88 (69.84)	257 (72.19)
Whether the pregnant woman herself has gender discrimination			0.471	0.493
Yes	28 (22.22)	90 (25.28)
No	98 (77.78)	266 (74.72)
Gender discrimination among family members			24.318	< 0.001
Yes	86 (68.25)	152 (42.70)
No	40 (31.75)	204 (57.30)
Whether regular birth inspection			1.846	0.174
Yes	84 (66.67)	260 (73.03)
No	42 (33.33)	96 (26.97)
History of adverse pregnancy outcomes			0.256	0.613
Yes	30 (23.81)	77 (21.63)
No	96 (76.19)	279 (78.37)
Systolic blood pressure (mean ± SD, mmHg)	149.57 ± 7.3	149.50 ± 8.08	-0.087	0.930
Diastolic blood pressure (mean ± SD, mmHg)	100.37 ± 5.97	99.62 ± 6.70	-1.113	0.266
Hemoglobin (mean ± SD, g/L)	108.47 ± 25.25	112.90 ± 30.02	1.700	0.090
Hct (mean ± SD, %)	63.16 ± 8.49	47.23 ± 6.18	-22.421	< 0.001
Platelets (mean ± SD, × 109/L)	137.72 ± 33.06	141.53 ± 32.63	1.121	0.263
Fibrinogen (mean ± SD, g/L)	4.38 ± 1.03	4.59 ± 1.11	1.749	0.081
Prothrombin time (mean ± SD, s)	10.96 ± 3.04	11.27 ± 3.01	0.991	0.322
Creatinine (mean ± SD, mmol/L)	60.64 ± 18.51	58.91 ± 16.86	-0.963	0.336
Urea nitrogen (mean ± SD, mmol/L)	4.16 ± 1.09	3.99 ± 0.97	-1.597	0.111
Alanine transaminase (mean ± SD, U/L)	27.21 ± 7.12	26.70 ± 7.23	-0.685	0.494
Aspartate aminotransferase (mean ± SD, U/L)	29.85 ± 9.05	28.82 ± 9.31	-1.071	0.285
Triglyceride (mean ± SD, mmol/L)	4.67 ± 1.08	4.18 ± 1.09	-1.657	0.098
Estradiol (mean ± SD, pg/mL)	50.23 ± 15.00	57.97 ± 11.95	5.845	< 0.001
Interleukin-6 (mean ± SD, pg/mL)	56.39 ± 12.22	40.24 ± 10.12	-14.554	< 0.001

Hct: Hematocrit.

Table 2 Multifactor logistic regression analysis of postpartum anxiety in pregnant women with preeclampsia

Factor	β	Wald χ2	P value	OR (95%CI)
bad marital relationship	0.880	4.594	0.032	2.412 (1.078-5.394)
Gender discrimination among family members	0.871	4.339	0.037	2.390 (1.053-5.425)
Hematocrit	0.130	35.391	< 0.001	1.139 (1.091-1.189)
Eastradiol	-0.044	8.039	0.005	0.957 (0.928-0.986)
Interleukin-6	0.286	64.504	< 0.001	1.331 (1.242-1.428)
Constant	-21.420	72.926	< 0.001

OR: Odds ratio; CI: Confidence interval.

Table 3 Clinical validation of the predictive model

Postpartum anxiety	Models predict postpartum anxiety		Total
	Yes	No
Yes	18	4	22
No	9	49	58
Total	27	53	80