Aberrant resting-state functional connectivity in amygdala subregions among adolescents with depression and suicide attempts

Figure 1 Subregions of the medial and lateral amygdala in the right and left hemispheres. L: Left; R: Right.

Figure 2 The brain regions with significant differences in resting-state functional connectivity of the amygdala subregions among the three groups. A: Brain regions with significant differences in resting-state functional connectivity (rsFC) of the left lateral amygdala (LA); B: Brain regions with significant differences in rsFC of the right LA; C: Brain regions with significant differences in rsFC of the medial amygdala. P < 0.001 for voxel level and P < 0.05 for cluster level, gaussian random field correction. The colored bars represent the F values. FFG: Fusiform gyrus; LA: Lateral amygdala; MeA: Medial amygdala; MOG: Middle occipital gyrus; PHG: Parahippocampal gyrus; STG: Superior temporal gyrus; THA: Thalamus.

Figure 3 Significant differences in the resting-state functional connectivity. A: Significant differences in the resting-state functional connectivity (rsFC) between the two groups in the left lateral amygdala (LA); B: Significant differences in the rsFC between the two groups in the right LA; C: Significant differences in the rsFC between the two groups in the medial amygdala. Bonferroni correction. P < 0.016. The colored bars represent the t values. FFG: Fusiform gyrus; IOG: Inferior occipital gyrus; LA: Lateral amygdala; MeA: Medial amygdala; MOG: Middle occipital gyrus; PHG: Parahippocampal gyrus; THA: Thalamus; TPOsup: Temporal pole: Superior temporal gyrus.

Figure 4 Correlation analysis between resting-state functional connectivity of amygdala subregions and clinical scale scores. A: Resting-state functional connectivity (rsFC) between the right medial amygdala and the right temporal pole: Superior temporal gyrus was negatively correlated with scores on the Rosenberg Self-Esteem Scale; B: The rsFC between the left lateral amygdala and the right parahippocampal gyrus was positively correlated with interpersonal relationship scores. rsFC: Resting-state functional connectivity.