Inter-relationships between isotretinoin treatment and psychiatric disorders: Depression, bipolar disorder, anxiety, psychosis and suicide risks

doi:10.5498/wjp.v5.i2.222

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World Journal of Psychiatry

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2220-3206

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World J Psychiatr. Jun 22, 2015; 5(2): 222-227
Published online Jun 22, 2015. doi: 10.5498/wjp.v5.i2.222

Inter-relationships between isotretinoin treatment and psychiatric disorders: Depression, bipolar disorder, anxiety, psychosis and suicide risks

Maude Ludot, Stephane Mouchabac, Florian Ferreri

Maude Ludot, Stephane Mouchabac, Florian Ferreri, Psychiatry and Medical Psychology Department, Hospital Saint-Antoine, Univ Paris 06, F-75012 Paris, France

Author contributions: All authors contributed equally to this work.

Conflict-of-interest: None.

Correspondence to: Florian Ferreri, MD, PhD, Psychiatry and Medical Psychology Department, Hospital Saint-Antoine, Univ Paris 06, Service de psychiatrie, 184 rue du faubourg Saint-Antoine, F-75012 Paris, France. florian.ferreri@upmc.fr

Telephone: +33-149-282635 Fax: +33-149-282010

Received: November 29, 2014
Peer-review started: Novmber 29, 2014
First decision: December 26, 2014
Revised: February 14, 2015
Accepted: May 5, 2015
Article in press: May 6, 2015
Published online: June 22, 2015
Processing time: 202 Days and 8.3 Hours

Core Tip

Core tip: Isotretinoin is a treatment for severe acne. The prescription of this drug has been controversial ever since its initial marketing in 1982. This paper aims to specify the links between the drug and psychiatric disorders such as depression, suicide, anxiety, bipolar disorder and psychosis. Many studies demonstrated an increased risk of depression, attempted suicide and suicide following isotretinoin treatment. Several studies showed that patients with bipolar disorder had an increased risk for a clinical exacerbation of symptoms undergoing treatment with isotretinoin. A few studies also seem to suggest a possible link between isotretinoin and psychosis. From this review, we propose guidelines for isotretinoin prescription to healthcare professionals.