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World J Psychiatry. Aug 19, 2026; 16(8): 117122
Published online Aug 19, 2026. doi: 10.5498/wjp.v16.i8.117122
Published online Aug 19, 2026. doi: 10.5498/wjp.v16.i8.117122
Sertraline plus psychological intervention for acute myocardial infarction with anxiety-depression comorbidity: Cardiac function, adverse mood, and resilience impacts
Ling-Jun Chu, Department of Pharmacy, Tonglu County Maternal and Child Health Hospital, Hangzhou 311500, Zhejiang Province, China
Jia-Ni Lv, Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, Zhejiang Province, China
Author contributions: Chu LJ designed the research and wrote the first manuscript; Chu LJ and Lv JN contributed to conceiving the research and analyzing data, conducted the analysis and provided guidance for the research; and all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Tonglu County Maternal and Child Health Hospital, No. 3.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: The data used to conduct the research are available from the corresponding author upon request.
Corresponding author: Ling-Jun Chu, Department of Pharmacy, Tonglu County Maternal and Child Health Hospital, No. 168 Baiyunyuan West Road, Chengnan Street, Hangzhou 311500, Zhejiang Province, China. tlzph@sohu.com
Received: March 10, 2026
Revised: April 20, 2026
Accepted: May 15, 2026
Published online: August 19, 2026
Processing time: 134 Days and 14.4 Hours
Revised: April 20, 2026
Accepted: May 15, 2026
Published online: August 19, 2026
Processing time: 134 Days and 14.4 Hours
Core Tip
Core Tip: Acute myocardial infarction (AMI) complicated by anxiety and depression adversely affects treatment compliance and smooth recovery. This study evaluated whether adding sertraline (STL) to psychological intervention can further improve heart function, mood, and resilience of such patients. The results indicate that STL combined with psychological intervention was more effective than psychological intervention alone in improving cardiac function, mood, resilience, sleep, and quality of life, supporting its clinical value in managing AMI patients with comorbid anxiety and depression.