Sertraline plus psychological intervention for acute myocardial infarction with anxiety-depression comorbidity: Cardiac function, adverse mood, and resilience impacts

doi:10.5498/wjp.v16.i8.117122

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Aug 19, 2026; 16(8): 117122
Published online Aug 19, 2026. doi: 10.5498/wjp.v16.i8.117122

Sertraline plus psychological intervention for acute myocardial infarction with anxiety-depression comorbidity: Cardiac function, adverse mood, and resilience impacts

Ling-Jun Chu, Jia-Ni Lv

Ling-Jun Chu, Department of Pharmacy, Tonglu County Maternal and Child Health Hospital, Hangzhou 311500, Zhejiang Province, China

Jia-Ni Lv, Department of Pharmacy, The First Aﬃliated Hospital of Zhejiang Chinese Medical University, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, Zhejiang Province, China

Author contributions: Chu LJ designed the research and wrote the first manuscript; Chu LJ and Lv JN contributed to conceiving the research and analyzing data, conducted the analysis and provided guidance for the research; and all authors reviewed and approved the final manuscript.

Institutional review board statement: This study was approved by the Ethic Committee of Tonglu County Maternal and Child Health Hospital, No. 3.

Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.

Conflict-of-interest statement: There is no conflict of interest.

Data sharing statement: The data used to conduct the research are available from the corresponding author upon request.

Corresponding author: Ling-Jun Chu, Department of Pharmacy, Tonglu County Maternal and Child Health Hospital, No. 168 Baiyunyuan West Road, Chengnan Street, Hangzhou 311500, Zhejiang Province, China. tlzph@sohu.com

Received: March 10, 2026
Revised: April 20, 2026
Accepted: May 15, 2026
Published online: August 19, 2026
Processing time: 134 Days and 10 Hours

Abstract

BACKGROUND

Medication compliance in patients with acute myocardial infarction (AMI) is often affected by negative emotions, hindering recovery.

AIM

To elucidate the effects of sertraline (STL) combined with psychological intervention on the cardiac function, adverse mood, and resilience in AMI patients with comorbid anxiety and depression (CAD).

METHODS

A total of 133 patients with AMI + CAD visiting our hospital between December 2021 and December 2024 were enrolled, including 60 patients receiving psychological intervention alone (control group) and 73 receiving STL in addition to the same intervention (research group). Data on cardiac function [cardiac output (CO), stroke volume (SV), left ventricular ejection fraction (LVEF)], adverse mood Hamilton Anxiety/Depression Scale (HAMA/HAMD), resilience Conner-Davidson Resilience Scale (CD-RISC), sleep quality Pittsburgh Sleep Quality Index (PSQI), and quality of life Short-Form 36 (SF-36) were analyzed.

RESULTS

Posttreatment, the research group showed significantly higher CO (4.94 ± 1.04 L/minute vs 4.25 ± 1.48 L/minute), SV (53.89 ± 7.89 mL vs 49.32 ± 5.39 mL), LVEF (64.47% ± 6.80% vs 58.30% ± 6.33%), CD-RISC (82.68 ± 6.74 vs 74.75 ± 6.23), and SF-36 scores [physical functioning: 75.74 ± 7.81 vs 70.65 ± 6.47; social functioning: 76.34 ± 7.49 vs 72.35 ± 6.98; role-emotional: 78.53 ± 7.05 vs 72.32 ± 6.92; mental health: 82.00 (76.00, 87.00) vs 77.00 (74.00, 79.00)], and lower HAMA (12.86 ± 3.65 vs 17.87 ± 4.29), HAMD (10.11 ± 2.90 vs 15.63 ± 3.04), and PSQI component scores than the control group.

CONCLUSION

The results indicate that STL combined with psychological intervention improves cardiac function, resilience, mood, sleep, and quality of life in AMI patients with CAD.

Keywords: Acute myocardial infarction; Comorbid anxiety and depression; Sertraline; Psychological intervention; Cardiac function

Core Tip: Acute myocardial infarction (AMI) complicated by anxiety and depression adversely affects treatment compliance and smooth recovery. This study evaluated whether adding sertraline (STL) to psychological intervention can further improve heart function, mood, and resilience of such patients. The results indicate that STL combined with psychological intervention was more effective than psychological intervention alone in improving cardiac function, mood, resilience, sleep, and quality of life, supporting its clinical value in managing AMI patients with comorbid anxiety and depression.