Feng P, Ji ZX, Zhang HY, Song KY, Chen LP, Qian HH, Wang B. Effect of apple phenols on anxiety/depression in a rat model of acute exacerbation of chronic obstructive pulmonary disease. World J Psychiatry 2026; 16(7): 117078 [DOI: 10.5498/wjp.117078]
Corresponding Author of This Article
Bu Wang, Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. fp202508@163.com
Research Domain of This Article
Medicine, Research & Experimental
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research-article
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Feng P, Ji ZX, Zhang HY, Song KY, Chen LP, Qian HH, Wang B. Effect of apple phenols on anxiety/depression in a rat model of acute exacerbation of chronic obstructive pulmonary disease. World J Psychiatry 2026; 16(7): 117078 [DOI: 10.5498/wjp.117078]
World J Psychiatry. Jul 19, 2026; 16(7): 117078 Published online Jul 19, 2026. doi: 10.5498/wjp.117078
Effect of apple phenols on anxiety/depression in a rat model of acute exacerbation of chronic obstructive pulmonary disease
Ping Feng, Ze-Xuan Ji, Hong-Yan Zhang, Kai-Yan Song, Li-Ping Chen, Hai-Hong Qian, Bu Wang
Ping Feng, Ze-Xuan Ji, Kai-Yan Song, Li-Ping Chen, Hai-Hong Qian, Bu Wang, Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Hong-Yan Zhang, Neurology III (Specialized in Psychiatry and Psychology), The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Author contributions: Feng P and Ji ZX designed the research study; Zhang HY and Song KY collected and analyzed the data; Feng P and Chen LP have been involved in drafting the manuscript; Feng P, Ji ZX, Zhang HY, Song KY, Chen LP, Qian HH, and Wang B performed the research; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by Zhangjiakou Science and Technology Bureau, No. 2322090D.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the First Affiliated Hospital of Hebei North University, approval No. EARIA20230711).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Corresponding author: Bu Wang, Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. fp202508@163.com
Received: January 9, 2026 Revised: February 9, 2026 Accepted: April 10, 2026 Published online: July 19, 2026 Processing time: 169 Days and 0 Hours
Core Tip
Core Tip: This study investigated the effects of apple polyphenols (AP) in a rat model of acute exacerbation of chronic obstructive pulmonary disease. Results demonstrated that AP treatment, particularly at high doses, effectively improved lung function and body weight and reduced pathological damage. It significantly downregulated the expression of NOD-like receptor protein 3 in lung tissue, leading to decreased levels of pro-inflammatory cytokines and oxidative stress markers in the serum, lung tissue, and prefrontal lobe tissue. Concurrently, AP alleviated anxiety and depression-like behaviors in acute exacerbation of chronic obstructive pulmonary disease model animals. This mechanism is associated with NOD-like receptor protein 3 pathway suppression.
