Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Psychiatry. Jun 19, 2026; 16(6): 113229
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.113229
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.113229
Jianpi Huazhuo Xiaoying Decoction plus emotional conditioning for thyroid nodule treatment: Impact on treatment outcomes and anxiety/depression
Jing Deng, Ling Wang, Medical College, Macau University of Science and Technology, Macau 999078, China
Jing Deng, Department of Medicine, Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
Chong Zhang, Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
Yu-Xin Xiao, Medical College, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan Province, China
Author contributions: Deng J designed the study; Deng J and Zhang C collected and analyzed the data, wrote the manuscript, and revised the manuscript; Deng J, Zhang C, Xiao YX, and Wang L participated in the collection of the data; and all authors approved the final version of the manuscript to be submitted.
Institutional review board statement: This study was approved by the Ethic Committee of Sichuan Provincial People’s Hospital, No. lunshen(yan)2024[651-1].
Informed consent statement: All research participants or their legal guardians provided written informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Ling Wang, MD, Medical College, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau 999078, China.
Received: September 23, 2025
Revised: November 18, 2025
Accepted: February 2, 2026
Published online: June 19, 2026
Processing time: 247 Days and 1.6 Hours
Revised: November 18, 2025
Accepted: February 2, 2026
Published online: June 19, 2026
Processing time: 247 Days and 1.6 Hours
Core Tip
Core Tip: A total of 123 patients diagnosed with thyroid nodules (TNs) were selected to analyze the clinical effects of Jianpi Huazhuo Xiaoying Decoction combined with emotional conditioning and standardized life interventions (emotional guidance + dietary adjustments + daily routine modifications). The combined treatment alleviated clinical symptoms and negative emotions, improved efficacy, reduced the number and average diameter of TNs, lowered microvascular density, and improved thyroid function. These findings support its use as a valuable therapeutic strategy for managing TNs.