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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Psychiatry. Apr 19, 2026; 16(4): 113317
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.113317
Risk factors and prediction model for depressive disorder in survivors of acute cerebral hemorrhage
Shi Tang, Tong-Da Xu, Yi Liang, Xing Ye, Hong-Ju Zhang, Rui Dai, Ge Yang, Xiang-Qing Kong, Wei Sun
Shi Tang, Yi Liang, Xing Ye, Hong-Ju Zhang, Rui Dai, Ge Yang, Department of Cardiology, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China
Tong-Da Xu, Department of Cardiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China
Xiang-Qing Kong, Wei Sun, Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China
Co-first authors: Shi Tang and Tong-Da Xu.
Co-corresponding authors: Xiang-Qing Kong and Wei Sun.
Author contributions: Tang S and Xu TD contributed equally as co-first authors; Tang S, Xu TD, Liang Y, Ye X, Zhang HJ, Dai R, Yang G, and Sun W contributed to data collection and paper writing; Kong XQ was responsible for funding application, reviewing and editing, communication coordination, ethical review, copyright and licensing, and follow-up; Kong XQ and Sun W contributed equally as co-corresponding authors; all authors did research design and data analysis and approved the final version to publish.
Institutional review board statement: The research was reviewed and approved by the Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, No. xyyll[2025]105.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No other data available.
Corresponding author: Xiang-Qing Kong, PhD, Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Gulou District, Nanjing 210000, Jiangsu Province, China. 15905218148@163.com
Received: September 23, 2025
Revised: October 23, 2025
Accepted: December 17, 2025
Published online: April 19, 2026
Processing time: 187 Days and 20.5 Hours
Core Tip

Core Tip: This study identified five independent risk factors (advanced age, deep hematoma, midline shift, low albumin, high modified Rankin Scale score) for post-intracerebral hemorrhage depression in the acute phase. A predictive model combining these factors demonstrated high discriminatory power (area under the curve = 0.885). This model aids in the early clinical screening of high-risk individuals, facilitating timely intervention to improve long-term prognosis. Key findings emphasize the roles of structural brain injury, systemic inflammation/malnutrition (reflected by albumin), and functional dependence in depression pathogenesis after acute intracerebral hemorrhage.