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World J Psychiatry. Mar 19, 2026; 16(3): 114342
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.114342
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.114342
Integrating traditional Chinese medicine and modern technology: A new approach to understanding Changmaxifeng granules for tic disorders
Ming-Qi Qiu, School of Pharmacy, Inner Mongolia Medical University (Jinshan Campus), Hoh
Wen-Jie Yang, Wu-Si Qiu, Department of Neurosurgery, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China
Ming-Min Chen, Department of General Practice, The First Affiliated Hospital, Zhejiang Uni
Co-corresponding authors: Wu-Si Qiu and Ming-Min Chen.
Author contributions: Qiu MQ and Qiu WS designed the study; Yang WJ and Qiu WS performed references acquisition and interpretation; Qiu MQ, Yang WJ, and Qiu WS wrote the manuscript; Qiu WS critically revised it for important intellectual content; Qiu WS and Chen MM contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors have read and approved the final manuscript.
Supported by the Clinical Research Fund Project of Zhejiang Medical Association, China, No. 2021ZYC-A80.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Wu-Si Qiu, MD, PhD, Associate Chief Physician, Associate Professor, Department of Neurosurgery, The Affiliated Hospital of Hangzhou Normal University, No. 126 Wenzhou Road, Gongshu District, Hangzhou 310015, Zhejiang Province, China.
Received: September 17, 2025
Revised: November 1, 2025
Accepted: December 15, 2025
Published online: March 19, 2026
Processing time: 163 Days and 15.5 Hours
Revised: November 1, 2025
Accepted: December 15, 2025
Published online: March 19, 2026
Processing time: 163 Days and 15.5 Hours
Core Tip
Core Tip: This article highlights a study that integrates modern analytical and computational methods to systematically uncover the multi-component, multi-target mechanism of Changmaxifeng granules for tic disorders. It identifies 75 blood-absorbed components and their key targets (e.g., tumor necrosis factor, interleukin-6, Fos proto-oncogene), highlighting Changmaxifeng granules’s potential in modulating neuroinflammation and synaptic signaling, and provides a framework for future personalized herbotherapy.