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World J Psychiatry. Mar 19, 2026; 16(3): 112649
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.112649
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.112649
Analysis of risk factors for postoperative depressive disorders in patients with intrauterine adhesions
Wen-Ling Du, Si-Si Zhan, Department of Gynecology, Wenzhou Central Hospital, Wenzhou 325000, Zhejiang Province, China
Shuang Chen, Department of Psychology, The First People’s Hospital of Shenyang, Shenyang 110031, Liaoning Province, China
Author contributions: Du WL participated in write original draft preparation and visualization; Du WL and Zhan SS contributed to data collection, statistical analysis; Chen S and Zhan SS contributed to review and edit the manuscript and methodology; Chen S contributed to psychological assessment design and implementation; Zhan SS contributed to conceptualization, supervision, project administration, funding acquisition. All authors contributed to manuscript revision and approved the final version.
Institutional review board statement: Approved by the Institutional Review Board of Wenzhou Central Hospital (approval No. 20250417629000402964).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.
Corresponding author: Si-Si Zhan, Attending Physician, Department of Gynecology, Wenzhou Central Hospital, No. 252 Baili East Road, Wuma Street, Lucheng District, Wenzhou 325000, Zhejiang Province, China. zhansisi@wmu.edu.cn
Received: August 8, 2025
Revised: September 16, 2025
Accepted: December 8, 2025
Published online: March 19, 2026
Processing time: 204 Days and 0.8 Hours
Revised: September 16, 2025
Accepted: December 8, 2025
Published online: March 19, 2026
Processing time: 204 Days and 0.8 Hours
Core Tip
Core Tip: Postoperative depression affects 28% of patients undergoing hysteroscopic adhesiolysis for intrauterine adhesions, representing a significantly higher rate than the general female population. Six independent risk factors were identified: Age ≥ 35 years, history of infertility, recurrent miscarriage, severe adhesions (grade III), postoperative complications, and previous depression or anxiety disorders. Three protective factors emerged: Higher education level, strong social support, and successful menstrual restoration within 3 months post-surgery.