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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Dec 19, 2025; 15(12): 109437
Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.109437
Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.109437
Psychocardiological impact of depression on medication adherence, ventricular function, and readmission in heart failure: A retrospective cohort study
Fu-Gang Mao, Ya-Ling Tang, Xing Jin, Department of Ultrasound Medicine, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China
Xiao-Yuan Wang, Department of Clinical Psychology, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China
Jing-Yuan Fan, Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China
Author contributions: Mao FG and Tang YL designed the research study; Mao FG and Fan JY drafted the manuscript; Wang XY and Jin X collected and organized the clinical data; Tang YL and Fan JY performed the statistical analysis and interpreted the results. All authors reviewed and approved the final version of the manuscript.
Institutional review board statement: This retrospective study was reviewed and approved by the Ethics Committee of The First People’s Hospital of Yunnan Province (Approval No. 2025-YNFPH-006).
Informed consent statement: Informed consent was waived by the Ethics Committee due to the retrospective design of the study and the use of anonymized clinical data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The datasets generated and analyzed during the current study are not publicly available due to institutional regulations and privacy concerns but are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Yuan Fan, PhD, Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming 650032, Yunnan Province, China. kelvin0720@163.com
Received: June 5, 2025
Revised: July 9, 2025
Accepted: October 22, 2025
Published online: December 19, 2025
Processing time: 175 Days and 1.7 Hours
Revised: July 9, 2025
Accepted: October 22, 2025
Published online: December 19, 2025
Processing time: 175 Days and 1.7 Hours
Core Tip
Core Tip: This real-world retrospective cohort study investigated the psychocardiological impact of depression on heart failure outcomes. Depression severity, measured by the Patient Health Questionnaire-9, was associated with poorer medication adherence, reduced left ventricular ejection fraction, and higher 1-year readmission risk. These findings underscore the need to incorporate psychosocial screening and interventions into routine heart failure management.