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World J Psychiatry. Nov 19, 2025; 15(11): 110699
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.110699
Interaction between anxiety, depression, and low resilience predicts poor prognosis in patients with chronic kidney disease
Jiang-Bo Li, Xiao-Bin Ye, Xi-Jin Tu
Jiang-Bo Li, Department of Psychosomatic, Jianyang People’s Hospital, Jianyang 641400, Sichuan Province, China
Xiao-Bin Ye, Xi-Jin Tu, Department of Psychiatry, Zhangzhou Fourth People’s Hospital, Zhangzhou 363000, Fujian Province, China
Co-first authors: Jiang-Bo Li and Xiao-Bin Ye.
Author contributions: Li JB and Ye XB contributed to the research and design and they contributed equally to this manuscript as co-first authors. Li JB, Ye XB, and Tu XJ wrote the manuscript. All authors contributed to this work and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang-Bo Li, Department of Psychosomatic, Jianyang People’s Hospital, No. 180 Hospital Road, Jianyang 641400, Sichuan Province, China. 1015950973@qq.com
Received: June 13, 2025
Revised: July 9, 2025
Accepted: September 18, 2025
Published online: November 19, 2025
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Core Tip

Core Tip: Studies have revealed that patients with chronic kidney disease (CKD) on long-term hemodialysis may experience mental health impairment. Multiple factors can exacerbate anxiety and depression; it interacts with the physiological processes of CKD, forming a pathological psychophysiological interaction mechanism that affects their quality of life and prognosis. A comprehensive management approach for patients with CKD should include a multidisciplinary medical team, personalized non-pharmacological intervention, and integrated pharmacological therapy. Assessing the risk-benefit ratio of antidepressants and hypnotics and drug intervention combined with non-drug intervention may help alleviate anxiety and depression, improve quality of life, break the psychophysiological vicious cycle, and optimize long-term outcomes.