Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Nov 19, 2025; 15(11): 109156
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.109156
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.109156
Effect of amino acid-balanced diet-based nutritional-psychological intervention on muscle wasting and quality of life in cirrhosis patients
Wei-Wei Zhuge, Lin-Xiu Zheng, Li-Juan Xu, Si-Fang Zhou, Hai-Xin Yao, Department of Nurse, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang Province, China
Author contributions: Zhuge WW and Zheng LX designed the research study; Zhuge WW, Zheng LX, Xu LJ, Zhou SF, and Yao HX performed the research; Zhuge WW and Zhou SF have been involved in drafting the manuscript and all authors have been involved in revising it critically for important intellectual content; Zheng LX and Xu LJ collected and analyzed the date. All authors give final approval of the version to be published.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee in Clinical Research of the First Affiliated Hospital of Wenzhou Medical University (Approval No. KY2023-298).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Xin Yao, Department of Nurse, The First Affiliated Hospital of Wenzhou Medical University, No. 2 Fuxue Lane, Wenzhou 325015, Zhejiang Province, China. yhxing8558@163.com
Received: June 17, 2025
Revised: July 9, 2025
Accepted: September 17, 2025
Published online: November 19, 2025
Processing time: 139 Days and 18.5 Hours
Revised: July 9, 2025
Accepted: September 17, 2025
Published online: November 19, 2025
Processing time: 139 Days and 18.5 Hours
Core Tip
Core Tip: This retrospective study of 130 cirrhosis patients compared conventional care (control) vs integrated amino acid-balanced dietary and psychological interventions (observation). At 3 months and 6 months, the observation group exhibited significantly lower anxiety/depression scores, greater grip and lower limb muscle strength, and superior quality of life (Chronic Liver Disease Questionnaire scores) vs controls (all P < 0.05). Findings suggest that amino acid-focused nutritional and psychological strategies mitigate muscle wasting and enhance psychosocial and physical outcomes in cirrhosis, warranting clinical adoption.