From physiology to psychology: An integrative review of menopausal syndrome

doi:10.5498/wjp.v15.i11.108713

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Nov 19, 2025 (publication date) through Nov 4, 2025

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Nov 19, 2025; 15(11): 108713
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.108713

From physiology to psychology: An integrative review of menopausal syndrome

Xiao-Lin Lang, Chang-Chang Huang, Hong-Yin Cui, Huan-Xin Zhong, Min-Yan Shen, Fen Zhao

Xiao-Lin Lang, Chang-Chang Huang, Hong-Yin Cui, Huan-Xin Zhong, Min-Yan Shen, Fen Zhao, Department of Gynecology, First People’s Hospital of Linping District, Hangzhou 310000, Zhejiang Province, China

Author contributions: Lang XL and Huang CC conducted literature search and wrote the original draft; Cui HY, Zhong HX, and Shen MY contributed to data analysis and manuscript revision; Zhao F conceived the study, supervised the project, and provided critical review. All authors approved the final manuscript.

Supported by Zhejiang Provincial Medical and Health Science and Technology Program, No. 2025KY196.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Fen Zhao, Department of Gynecology, First People’s Hospital of Linping District, No. 369 Yingbin Road, Linping District, Hangzhou 310000, Zhejiang Province, China. zhaofen0508@126.com

Received: May 23, 2025
Revised: June 29, 2025
Accepted: September 10, 2025
Published online: November 19, 2025
Processing time: 164 Days and 17.8 Hours

Core Tip

Core Tip: This integrative review explores how hormonal fluctuations during menopause contribute to anxiety and depression through neuroendocrine, neuroinflammatory, genetic, psychosocial, and cognitive mechanisms. By bridging physiology and psychology, the paper highlights the complexity of menopausal mental health and advocates for a biopsychosocial framework in clinical care. Understanding these interconnected pathways can inform personalized interventions - ranging from hormone therapy to psychotherapy and lifestyle adjustments - and guide future research on biomarkers and targeted treatments to support emotional wellbeing in midlife women.