Liu MH, Wu LL. Heart rate variability associated with depression and lung decline in chronic obstructive pulmonary disease: Mechanisms and interventions. World J Psychiatry 2025; 15(11): 108591 [DOI: 10.5498/wjp.v15.i11.108591]
Corresponding Author of This Article
Li-Li Wu, PhD, Associate Professor, Department of Developmental Psychology of Armyman, Army Medical University, No. 30 Gaotanyan Zhengjie, Shapingba District, Chongqing 400038, China. wulili080241@163.com
Research Domain of This Article
Psychiatry
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Editorial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 19, 2025 (publication date) through Nov 3, 2025
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Journal Information of This Article
Publication Name
World Journal of Psychiatry
ISSN
2220-3206
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Liu MH, Wu LL. Heart rate variability associated with depression and lung decline in chronic obstructive pulmonary disease: Mechanisms and interventions. World J Psychiatry 2025; 15(11): 108591 [DOI: 10.5498/wjp.v15.i11.108591]
World J Psychiatry. Nov 19, 2025; 15(11): 108591 Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.108591
Heart rate variability associated with depression and lung decline in chronic obstructive pulmonary disease: Mechanisms and interventions
Mei-He Liu, Li-Li Wu
Mei-He Liu, Li-Li Wu, Department of Developmental Psychology of Armyman, Army Medical University, Chongqing 400038, China
Author contributions: Liu MH and Wu LL contributed to this paper, designed the overall concept, and outline of the manuscript; Liu MH contributed to the writing, and editing the manuscript; Wu LL contributed to the discussion and design of the manuscript, and review of literature; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Li Wu, PhD, Associate Professor, Department of Developmental Psychology of Armyman, Army Medical University, No. 30 Gaotanyan Zhengjie, Shapingba District, Chongqing 400038, China. wulili080241@163.com
Received: April 18, 2025 Revised: May 25, 2025 Accepted: August 12, 2025 Published online: November 19, 2025 Processing time: 199 Days and 15.2 Hours
Core Tip
Core Tip: The comorbidity of chronic obstructive pulmonary disease and depression severely impacts patients’ health. This editorial explores associations and clinical implications among heart rate variability (HRV), depression, and lung function in chronic obstructive pulmonary disease patients, emphasizing the inflammatory-autonomic-oxidative stress pathway as the core mechanism. It reveals the effects of genetic polymorphisms, environmental factors, and their interactions on HRV differences and comorbidity risk, and further highlights HRV’s longitudinal predictive value in lung function decline and real-time monitoring potential. We propose a comprehensive framework integrating HRV monitoring, multi-omics biomarkers, and machine learning for early intervention and improved patients’ quality of life.
