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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Nov 19, 2025; 15(11): 108292
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.108292
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.108292
Seizure recurrence after first epileptic episode in ischemic stroke: Risk factors and their association with cognition and mood
Shen-Yang Wang, Ni-Ni Li, Department of Neurology, Shaanxi Provincial People's Hospital, Xi’an 710068, Shaanxi Province, China
Dong-Dong Zhang, Department of Neurosurgery, Norinco General Hospital, Xi’an 710065, Shaanxi Province, China
Author contributions: Wang SY designed the research and wrote the first manuscript; Wang SY and Zhang DD contributed to conceiving the research and analyzing data; Wang SY and Li NN conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Shaanxi Provincial People's Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ni-Ni Li, MS, Department of Neurology, Shaanxi Provincial People's Hospital, No. 256 West Youyi Road, Xi’an 710068, Shaanxi Province, China.
Received: June 27, 2025
Revised: August 14, 2025
Accepted: September 17, 2025
Published online: November 19, 2025
Processing time: 128 Days and 23.2 Hours
Revised: August 14, 2025
Accepted: September 17, 2025
Published online: November 19, 2025
Processing time: 128 Days and 23.2 Hours
Core Tip
Core Tip: In a cohort of 100 patients with ischemic stroke, we identified delayed seizure onset, cortical lesions, and hemorrhagic infarction as key predictors of recurrent seizures following a first episode. These risk factors also showed strong associations with cognitive impairment and emotional distress.