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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Oct 19, 2025; 15(10): 109425
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.109425
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.109425
Brain region and cell specificity of B4GALT6 in mice with depressive-like behavior: A pilot study
Shi-Na Zhang, Bing Xie, Le Xiao, Department of Rehabilitation Medicine, The First Hospital of Changsha (The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University), Changsha 410005, Hunan Province, China
Di Luan, Department of Neurology, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Bo-Yang Sheng, School of Traditional Chinese Medicine, Hunan University of Chinese Me
Co-corresponding authors: Le Xiao and Bing Xie.
Author contributions: Xiao L and Xie B contributed equally to this study as co-corresponding authors; Zhang SN and Xiao L were responsible for conceptualization, methodology, formal analysis, investigation, data curation, writing – original draft, writing - review & editing, supervision, and project administration; Luan D was responsible for conceptualization, methodology, formal analysis, investigation, data curation, writing – original draft, and writing - review & editing; Sheng BY was responsible for conceptualization, formal analysis, writing – original draft, and visualization; Xie B was responsible for conceptualization, formal analysis, writing – original draft, writing – review & editing supervision, and project administration.
Supported by Hunan Provincial Natural Science Foundation of China, No. 2025JJ80473 and No. 2025JJ80484; and the Institute of Hospital Management, National Health Commission of China, Major Project, No. SZ2024HL021.
Institutional animal care and use committee statement: This study was approved by the Experimental Animal Ethics Committee of Southeast University, with approval No. 20220104003.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The authors confirm that the data supporting the findings of this study are available within the article and its supplementary materials.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Le Xiao, BS, Chief Physician, Department of Rehabilitation Medicine, The First Hospital of Changsha (The Affiliated Changsha Hospital of Xiangya School of Me
Received: May 12, 2025
Revised: June 27, 2025
Accepted: August 8, 2025
Published online: October 19, 2025
Processing time: 139 Days and 1.2 Hours
Revised: June 27, 2025
Accepted: August 8, 2025
Published online: October 19, 2025
Processing time: 139 Days and 1.2 Hours
Core Tip
Core Tip: Major depressive disorder (MDD) poses a serious threat to human life. The single nucleotide polymorphism rs372369000 located within the B4GALT6 gene is a risk locus for MDD. However, the pathological mechanism of B4GALT6 in the brain in relation to MDD remains unclear. We developed an inflammation-associated depression model and examined B4GALT6-like immunoreactivity distribution and levels throughout the brain. The expression of B4GALT6-like immunoreactivity increased in the hippocampus, PrL, and the visual cortex V1 region of MDD mice. This elevation varied across different brain subregions and cell types. Taken together, our data suggest that B4GALT6 may be a potential therapeutic target for MDD.