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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Oct 19, 2025; 15(10): 108712
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.108712
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.108712
Anxiety and depression in patients with hepatobiliary and pancreatic malignancies: Influence of disease stage and psychosocial factors
Xiao Yu, Shuai Wang, Department of Hepatobiliary Surgery, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou 434020, Hubei Province, China
Xiao He, Department of Psychiatry, Jingzhou Mental Health Center, Jingzhou 434000, Hubei Province, China
Co-first authors: Xiao Yu and Xiao He.
Author contributions: Yu X and He X designed the research study; Yu X and He X performed the primary literature review and data extraction; Yu X and He X analyzed the data and wrote the manuscript; Yu X and Wang L revised the manuscript for important intellectual content, jointly designed the research framework and methodology, performed literature review, data extraction, and data analysis; Yu X and He X co-drafted the manuscript and revised it critically for intellectual content. All authors have read and approved the final version.
Institutional review board statement: This study was reviewed and approved by the Science and Research Office of Jingzhou Hospital Affiliated to Yangtze University (NO.2025-117-01).
Informed consent statement: All study participants or their legal guardians provided written informed consent for personal and medical data collection before enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shuai Wang, PhD, Department of Hepatobiliary Surgery, Jingzhou Hospital Affiliated to Yangtze University, Chuyuan Avenue, Jingzhou District, Jingzhou 434020, Hubei Province, China. l10095@yangtzeu.edu.cn
Received: June 24, 2025
Revised: July 25, 2025
Accepted: August 13, 2025
Published online: October 19, 2025
Processing time: 94 Days and 1.3 Hours
Revised: July 25, 2025
Accepted: August 13, 2025
Published online: October 19, 2025
Processing time: 94 Days and 1.3 Hours
Core Tip
Core Tip: Patients with hepatobiliary and pancreatic malignancies often experience comorbid anxiety and depression; however, the association between disease stage and psychological status remains unclear. This study uniquely compared early-stage (IA-IB) and intermediate-stage (IIA-IIIA) patients with healthy controls. Significantly higher anxiety detection rates and life event scores were observed in intermediate-stage patients, highlighting disease progression as a key burden. We propose integrating psychological interventions into comprehensive cancer care to enhance treatment efficacy and quality of life.