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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jun 19, 2024; 14(6): 866-875
Published online Jun 19, 2024. doi: 10.5498/wjp.v14.i6.866
Published online Jun 19, 2024. doi: 10.5498/wjp.v14.i6.866
Effects of serum inflammatory factors, health index and disease activity scores on ankylosing spondylitis patients with sleep disorder
Hui Wang, Jia-Ying Sun, Yue Zhang, Department of Rheumatology and Immunology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Wang H and Zhang Y initiated the project, designed the experiment and conducted clinical data collection; Sun JY performed postoperative follow-up and recorded data; Wang H and Zhang Y conducted collation and statistical analyses and wrote the original manuscript; All the authors read and approved the final manuscript.
Supported by the Immuno Inflammatory Diseases Research Support Project , No. J202301E036 .
Institutional review board statement: This study was approved by the Ethics Committee of the First Affiliated Hospital of Harbin Medical University.
Informed consent statement: The Ethics Committee has agreed to waive informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data generated or analysed during this study are included in this published article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yue Zhang, BMed, Nurse, Department of Rheumatology and Immunology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. ilovexibi@126.com
Received: February 29, 2024
Revised: April 28, 2024
Accepted: May 22, 2024
Published online: June 19, 2024
Processing time: 111 Days and 4.3 Hours
Revised: April 28, 2024
Accepted: May 22, 2024
Published online: June 19, 2024
Processing time: 111 Days and 4.3 Hours
Core Tip
Core Tip: This study highlights the intricate associations between serum inflammatory factors, health index, and disease activity scores in ankylosing spondylitis (AS) patients with comorbid sleep disorders. Elevated serum inflammatory markers, including C-reactive protein, erythrocyte sedimentation rate, interleukin-6 (IL-6), tumor necrosis factor-alpha, and IL-1β, are linked to increased disease activity, while the health index is negatively correlated with disease activity scores. These findings underscore the complexity of managing AS patients with concurrent sleep disturbances and emphasize the need for comprehensive care strategies that integrate systemic inflammation, disease activity, and patient-reported health outcomes.