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World J Psychiatr. Oct 19, 2021; 11(10): 774-790
Published online Oct 19, 2021. doi: 10.5498/wjp.v11.i10.774
‘Omics’ of suicidal behaviour: A path to personalised psychiatry
Katarina Kouter, Alja Videtic Paska
Katarina Kouter, Alja Videtic Paska, Faculty of Medicine, Institute of Biochemistry and Molecular Genetics, University of Ljubljana, Ljubljana SI-1000, Slovenia
Author contributions: Videtic Paska A and Kouter K organized and planned the manuscript; Kouter K wrote a part of MS regarding use of omics in suicidal behaviour research: Epigenomics, proteomics, and building the bridge between personalised medicine and psychiatry; Videtic Paska A wrote the introduction, use of omics in suicidal behaviour research: Genomics, metabolomics; all authors approved the final version of the manuscript; Kouter K and Videtic Paska A declare equal contribution to this manuscript.
Supported by the Slovenian Research Agency Research Programme, No. P1-0390, No. J3-7132, and No. Z3-2653.
Conflict-of-interest statement: Nothing to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alja Videtic Paska, PhD, Associate Professor, Faculty of Medicine, Institute of Biochemistry and Molecular Genetics, University of Ljubljana, Vrazov Trg 2, Ljubljana SI-1000, Slovenia. alja.videtic@mf.uni-lj.si
Received: February 27, 2021
Peer-review started: February 27, 2021
First decision: July 15, 2021
Revised: July 16, 2021
Accepted: August 30, 2021
Article in press: August 30, 2021
Published online: October 19, 2021
Processing time: 229 Days and 16.1 Hours
Core Tip

Core Tip: Suicide is major public health concern worldwide, and at the same time, it is preventable when timely measures are taken. The biological basis of suicidal behaviour is not a product of a single gene, transcript, protein or metabolite; rather, it is represented by intertwined cellular mechanisms, cell types and tissue changes, and based on numerous molecular pathways. The ‘-omic’ technologies might represent the missing link between the current state of psychiatry and future personalised approaches, through the combination of -omics-derived information and the diagnostic process. However, first we need precise, specific and validated biomarkers.