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Randomized Controlled Trial
Copyright ©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Feb 19, 2026; 16(2): 112054
Published online Feb 19, 2026. doi: 10.5498/wjp.v16.i2.112054
Internet plus-based post-discharge continuity care for mild-to-moderate depression: An exploratory study
Pei-Pei Lin, Wei-Wei Lv, Chun-Mian Chen
Pei-Pei Lin, Department of General Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou 325000, Zhejiang Province, China
Wei-Wei Lv, Department of Integrated Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou 325000, Zhejiang Province, China
Chun-Mian Chen, Dean’s Office, Wenzhou Seventh People’s Hospital, Wenzhou 325000, Zhejiang Province, China
Co-corresponding authors: Wei-Wei Lv and Chun-Mian Chen.
Author contributions: Lin PP conceptualized and designed the study, conducted patient recruitment and clinical assessments, performed data collection and preliminary analysis, and drafted the initial manuscript; Lv WW led the implementation of the “Internet+” nursing intervention, supervised data acquisition and quality control, conducted statistical analysis and interpretation, revised the manuscript critically for intellectual content, and approved the final version for submission; Chen CM provided methodological guidance and study oversight, secured ethical approval and institutional resources, validated statistical results and clinical implications, edited and finalized the manuscript, and corresponded with journal editorial teams; Lv WW and Chen CM contributed equally to this article as the co-corresponding authors of this manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Wenzhou Basic Research Project, No. Y2023735.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Wenzhou Seventh People’s Hospital (approval No. (2024) 16).
Informed consent statement: Written informed consent was obtained from all participating patients and their legal guardians.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: In accordance with medical data confidentiality principles, de-identified research data may be obtained upon reasonable request to the corresponding author. Data sharing must comply with hospital data management regulations and require the signing of a confidentiality agreement.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Wei Lv, Department of Integrated Psychiatry, Wenzhou Seventh People’s Hospital, No. 158 Xueshi Qian Road, Panqiao Subdistrict, Ouhai District, Wenzhou 325000, Zhejiang Province, China. 13858859553@163.com
Received: July 22, 2025
Revised: August 26, 2025
Accepted: November 12, 2025
Published online: February 19, 2026
Processing time: 191 Days and 23 Hours
Abstract
BACKGROUND

Depression is a prevalent global mental health disorder affecting over 300 million individuals, with studies indicating a 34% rise in cases from 2001 to 2020. In China, depression accounts for 3.0% of psychiatric disorders among adolescents, severely impairing patients’ quality of life. Despite pharmacological efficacy in acute-phase treatment, post-discharge relapse rates remain high (50% within one year), highlighting the need for effective continuity-of-care interventions. Traditional follow-up models (e.g., outpatient visits or telephone calls) face limitations, including inefficient symptom monitoring and low medication adherence (26.4% decline post-discharge). Emerging evidence supports “Internet”-based interventions, such as cognitive behavioral therapy, which improve adherence (76% vs 54%) and outcomes. However, few studies have explored "Internet+"-enabled extended nursing for mild-to-moderate depression. This study investigates an integrated “Internet+” continuity-of-care model leveraging WeChat to enhance post-discharge management, targeting anxiety/depression reduction, cognitive improvement, and nurse professional identity.

AIM

To explore the application of the “Internet+” concept in post-discharge continuity of care for patients with mild to moderate depression.

METHODS

From January 2024 to December 2024, 82 patients with mild and moderate depression who met the discharge criteria were selected as participants and randomly divided into an observation group and a control group (n = 41 each). The control group received conventional continuity care, while the observation group was provided with an integrated “Internet+”-based extended nursing model in addition to standard care. Both groups underwent a comprehensive three-month intervention program. Comparative assessments were conducted between the two groups regarding anxiety and depression levels, cognitive function, medication adherence, satisfaction rates, quality of life, and nursing staff’s professional identity.

RESULTS

After the intervention, the observation group demonstrated significantly superior outcomes compared to the control group (P < 0.05 for all). Specifically, they exhibited lower scores on the Hamilton Anxiety Scale (7.14 ± 3.08) and Hamilton Depression Scale (6.11 ± 1.05), along with a higher score on the Montreal Cognitive Assessment Scale (26.82 ± 1.53). Medication compliance was also significantly higher in the observation group (90.24%) than in the control group (70.73%) (P < 0.05). Furthermore, patient satisfaction ratings across all surveyed domains—including overall satisfaction, the service effect of nursing staff, professional knowledge and skills, communication and listening abilities, time management and punctuality, friendliness and care, privacy protection, and the rationality of nursing service costs were significantly elevated in the observation group. After the intervention, both groups improved. Quality of life assessments revealed significantly better scores in the observation group across all dimensions: Physical function (51.31 ± 5.49), psychological function (44.49 ± 5.85), social function (43.62 ± 4.91), material life (46.21 ± 5.56), subjective perception of quality of life (3.57 ± 0.66), subjective perception of health status (3.57 ± 0.68), and total score (146.21 ± 12.37). Finally, the score of professional identity in the observation group was 28.49 ± 4.62, which was significantly higher than that of the control group (P < 0.05). And the professional identity of nurses in the observation group after the intervention was negatively correlated with anxiety and depression (P < 0.05), and positively correlated with cognition and medication compliance (P < 0.05).

CONCLUSION

“Internet+” continuous nursing can effectively improve the anxiety and depressive symptoms and cognitive function of patients with mild to moderate depression, improve their medication compliance, quality of life, and nursing satisfaction, and enhance the professional identity of nurses, which is worthy of clinical promotion and application.

Keywords: Internet+; Mild-to-moderate depression; Post-discharge; Continuity of care; Nursing intervention

Core Tip: This study investigates the impact of an “Internet+”-based extended care model on patients with mild to moderate depression following hospital discharge. It demonstrates that integrating Internet-based real-time supervision, reminders, and education significantly reduces anxiety and depressive symptoms (measured by Hamilton Anxiety Scale and Hamilton Depression Scale scores), enhances cognitive function (Montreal Cognitive Assessment Scale scores), and improves medication adherence and quality of life compared to traditional care methods. Furthermore, this innovative approach boosts patient satisfaction and strengthens nursing staff’s professional identity, highlighting its potential as a scalable intervention for post-hospital treatment of depression.