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World J Psychiatry. Dec 19, 2025; 15(12): 109408
Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.109408
Effect of mindfulness stress reduction combined with cognitive behavioral therapy on perinatal anxiety disorder and maternal-infant bonding
Jia-Di Ge, Chen Tang, Ying Shen
Jia-Di Ge, Chen Tang, Ying Shen, Delivery Room, Affiliated Hospital of Jiangnan University, Wuxi 214000, Jiangsu Province, China
Author contributions: Ge JD designed the study and analyzed the data; Ge JD, Tang C, and Shen Y were involved in the data collection and writing of this article. All the authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Affiliated Hospital of Jiangnan University, No. LS2025259.
Clinical trial registration statement: The study was registered at the Clinical Trial Center (www.researchregistry.com), No. 11396.
Informed consent statement: All study participants and their legal guardians provided written informed consent before enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Shen, Chief Nurse, Delivery Room, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Wuxi 214000, Jiangsu Province, China. sy13771087669@126.com
Received: July 4, 2025
Revised: August 6, 2025
Accepted: September 29, 2025
Published online: December 19, 2025
Processing time: 146 Days and 1.2 Hours
Abstract
BACKGROUND

Perinatal anxiety disorder is the main problem affecting mother-infant bonding. Though the impact of perinatal anxiety in primiparous women on the mother-infant relationship is well established, appropriate interventions need to be explored.

AIM

To explore the synergistic intervention effect of mindfulness-based stress reduction combined with cognitive behavioral therapy (CBT) on perinatal anxiety disorders and mother-infant bonding in primiparas.

METHODS

A total of 150 primiparas with perinatal anxiety disorders admitted to the hospital from January 2020 to October 2024 were selected and divided into two groups according to the random number method. The control group (n = 75) received CBT, and the observation group (n = 75) received mindfulness-based stress reduction combined with CBT. The anxiety and depressive emotions, as well as the mother-infant emotional bonding situation, were compared between the two groups.

RESULTS

After the intervention, the anxiety and depressive states in the observation group were lower than those in the control group (P < 0.05). The mother-infant bonding (sense of pleasure, recognition, understanding, and love) in the observation group was higher than that in the control group, and the role adaptation ability was also higher than in the control group (P < 0.05).

CONCLUSION

Mindfulness-based stress reduction combined with CBT can reduce perinatal anxiety disorders in primiparas, promote mother-infant bonding, and improve their ability to adapt to the mother role.

Keywords: Mindfulness stress reduction; Cognitive behavioral therapy; Primiparous women; Perinatal anxiety disorder; Mother-infant emotional bonding

Core Tip: Mindfulness-based stress reduction combined with cognitive behavioral therapy significantly reduces perinatal anxiety and depression in primiparas by enhancing self-regulation and correcting cognitive distortions. This synergistic approach strengthens mother-infant bonding through improved emotional recognition, role adaptation, and affectionate interactions, outperforming cognitive behavioral therapy alone. Prioritizing non-pharmacological interventions addresses perinatal mental health safely while promoting long-term maternal-infant relational health.