Retrospective evaluation of efficacy of CytoSorb® therapy in septic shock patients in a tertiary care intensive care unit

Table 1 Predicted mortality based on initial sepsis associated organ failure score

Initial sepsis associated organ failure score	Predicted mortality
0-1	0
2-3	6.0%
4-5	20.0%
6-7	21.5%
8-9	33.3%
10-11	50.0%
> 11	95.2%

Table 2 Demographic characteristics and comparison of laboratory and vital parameters pre- and post-therapy, n (%)/median (25^th-75^th percentiles)

Parameters	Overall patients (n = 87)
Gender (male)	59 (67.8)
Age (years)	63 (51-70)
Comorbidities
Diabetes	28 (32.2)
Hypertension	40 (46.0)
Chronic kidney disease	10 (11.5)
	Pre	Post	P value
Haemoglobin (gm/dL)	9.7 (8.8-11.9)	9.2 (8.1-10.3)	0.0007
Haematocrit (%)	30 (27-33)	30 (26.9-32)	0.866
Leucocytes (cells/mm3)	15680 (6880-28000)	11200 (5810-17100)	0.0001
Platelets (× 103/μL)	106 (44-208)	62 (34-121)	< 0.0001
LDH (U/L)	440.5 (260.5-933.5)	380 (156-1018)	0.2031
Creatinine (μmol/L)	1.57 (1.17-2.8)	1.3 (0.81-2)	< 0.0001
Lactate (mmol/L)	5 (3-11)	2.4 (1.3-7)	< 0.0001
Procalcitonin (ng/mL)	2.05 (0.57-23.6)	1.2 (0.2-9)	< 0.0001
C-reactive protein (mg/L)	210 (91-305)	97 (40-215)	< 0.0001
IL-6 (pg/mL)	4683.5 (1276-5000)	783.7 (181-3731.5)	0.0007
Albumin (gm/dL)	2.9 (2.5-3.4)	3.2 (2.9-3.7)	< 0.0001
PaO2/FiO2	175 (112-330)	225 (122-357)	0.1121
MAP (mmHg)	77 (73-86)	83 (76-90)	0.0130
Epinephrine dose (mcg/kg/min)	0.0 (0-0.09)	0 (0-0.05)	0.0004
NE dose (mcg/kg/min)	0.5 (0.2-0.75)	0.3 (0.08-0.6)	< 0.0001

LDH: Lactate dehydrogenase; PaO2/FiO2: Ratio of partial pressure of oxygen in blood, in millimetres of mercury, and the fraction of oxygen in the inhaled air; MAP: Mean arterial pressure; NE: Norepinephrine.

Table 3 Number and type of CytoSorb devices used and other conditions, n (%)/median (25^th-75^th percentiles)

Parameters (number of devices used)	Overall patients
1	43 (49.43)
2	25 (28.74)
3	11 (12.64)
≥ 4 type of dialysis support	8 (9.2)
CRRT	77 (88.5)
SLED	4 (4.6)
CRRT + SLED	4 (4.6)
CRRT + ECMO	2 (2.3)
Flow rate (mL/minute)	150 (120-150)
APTT/ACT	40 (35-45)
Patients requiring anticoagulation therapy	52 (61.2)
Heparin dosage (unit/hour)	200 (150-200)

ACT: Activated clotting time; APTT: Activated partial thromboplastin time; CRRT: Continuous renal replacement therapy; ECMO: Extracorporeal membrane oxygenation; SLED: Sustained low efficiency dialysis.