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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Dec 9, 2025; 14(4): 110669
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.110669
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.110669
Optic nerve sheath diameter trajectories and mortality in children with clinically relevant elevated intracranial pressure
Dat Minh-Tan Truong, Department of Intensive Care Unit, Children’s Hospital 2, Ho Chi Minh City 700000, Viet Nam
Minh Hoang-Nhat Nguyen, Department of Medicine, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Viet Nam
Huy Quang Nguyen, Department of Radiology, Children’s Hospital 2, Ho Chi Minh City 700000, Viet Nam
Luan Thanh Vo, Thanh Tat Nguyen, Department of Infectious Diseases, Children's Hospital 2, Ho Chi Minh City 700000, Viet Nam
Thanh Tat Nguyen, Department of Tuberculosis and Epidemiology, Woolcock Institute of Medical Research, Ho Chi Minh City 700000, Viet Nam
Author contributions: Truong DMT, Vo LT, Nguyen TT contributed to conceptualization, critical revision of the final manuscript; Truong DMT, Nguyen MHN, Nguyen HQ contributed to data curation, investigation; Nguyen TT contributed to formal analysis; Truong DMT, Nguyen TT contributed to writing-original draft, methodology; all authors have contributed to and approved the final manuscript.
Institutional review board statement: This study was conducted at Children’s Hospital 2, a tertiary care pediatric hospital in southern Vietnam. Ethical approval was granted by the Scientific Committee and Institutional Review Board of Children’s Hospital 2, Ho Chi Minh City (IRB No. 370/GCN-BVND2).
Informed consent statement: Informed consent was obtained from all participants. All procedures were performed in strict accordance with the principles of Good Clinical Practice and ethical standards outlined in the Declaration of Helsinki.
Conflict-of-interest statement: All authors declare that there is no conflict of interest.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement- checklist of items.
Data sharing statement: The original contributions of this study are included in the article and supplementary material. Further requests can be directed to the corresponding authors.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Thanh Tat Nguyen, MD, PhD, Department of Tuberculosis and Epidemiology, Woolcock Institute of Medical Research, Pham Ngoc Thach, Ho Chi Minh City 700000, Viet Nam. thanhhonor@gmail.com
Received: June 12, 2025
Revised: July 1, 2025
Accepted: September 24, 2025
Published online: December 9, 2025
Processing time: 170 Days and 2.6 Hours
Revised: July 1, 2025
Accepted: September 24, 2025
Published online: December 9, 2025
Processing time: 170 Days and 2.6 Hours
Core Tip
Core Tip: The in-hospital mortality rate in children hospitalized with clinically relevant raised intracranial pressure was 23.2%. Nonsurvivors had a median 5.3% increase in ultrasound-measured optic nerve sheath diameter (ONSD), whereas survivors showed median 5.6% reduction during the first 48 hours of admission. Early changes in ONSD, as measured by ultrasound during the first 48 hours of admission, were strongly correlated with neurological deterioration and mortality risk.