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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Dec 9, 2025; 14(4): 108907
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.108907
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.108907
Predictive accuracy of 4C Mortality Score and Acute Physiology and Chronic Health Evaluation scores for mortality in COVID-19 patients admitted to intensive care unit
Kush Deshpande, Department of Intensive Care, St George Hospital, Sydney 2217, New South Wales, Australia
Kush Deshpande, School of Medicine, University of New South Wales, Sydney 2033, New South Wales, Australia
Dushyant Tripathi, Intensive Care Unit, Maitland Hospital, Maitland 2323, New South Wales, Australia
Co-first authors: Kush Deshpande and Dushyant Tripathi.
Author contributions: Deshpande K and Tripathi D contributed to conceptualisation, literature review, writing original draft, review and editing; Deshpande K contributed to statistical analysis, validation, supervision; Tripathi D contributed to data collection.
Institutional review board statement: The ethics approval was obtained from the Human Research Ethics Committee, South Eastern Sydney Local Health District.
Informed consent statement: Not applicable.
Conflict-of-interest statement: There are no disclosures or conflicts of interest to declare.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Data sharing statement: The data supporting the findings of this study will be made available upon request by the authors.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kush Deshpande, MD, Consultant, Department of Intensive Care, St George Hospital, Gray Street, Kogarah, NSW 2217, Sydney 2217, New South Wales, Australia. kush.deshpande@health.nsw.gov.au
Received: April 27, 2025
Revised: June 2, 2025
Accepted: August 29, 2025
Published online: December 9, 2025
Processing time: 217 Days and 12 Hours
Revised: June 2, 2025
Accepted: August 29, 2025
Published online: December 9, 2025
Processing time: 217 Days and 12 Hours
Core Tip
Core Tip: This retrospective cohort study compared the predictive accuracy of the 4c Mortality Score and Acute Physiology and Chronic Health Evaluation (APACHE) II and III scores for coronavirus disease 2019 patients admitted to intensive care unit (ICU). The 4C score at ICU admission showed an area under the receiver operating characteristic curve of 0.80, higher than at hospital admission (0.75) and comparable to APACHE III (0.79) and II (0.75). Non-survivors were older, predominantly male, with more comorbidities and higher intervention rates. The study suggests that the 4C score at ICU admission is a reliable predictor of mortality and is easier to calculate. These findings warrant further validation in a larger study.