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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Dec 9, 2025; 14(4): 108689
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.108689
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.108689
Outcome predictors of systemic lupus erythematosus requiring admission to the intensive care unit
Anitha P Mampilly, Rajnin Nanda, Vaanya Bansal, Department of Critical Care, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India
Binila Chacko, John V Peter, Department of Medical Intensive Care, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India
John Mathew, Department of Rheumatology, Christian Medical College, Vellore 632004, Tamil Nadu, India
Krupa George, Anna Paul, Department of General Medicine, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India
Sudha Jasmine, Samuel George, Karthik Gunasekaran, Department of Medicine, Christian Medical College Vellore, Vellore 632004, Tamil Nadu, India
Author contributions: Mampilly AP and Peter JV discussed and designed the study; Mampilly AP wrote the first draft of the manuscript; Chacko B and Peter JV revised the first draft; Mathew J, George K, Paul A, Jasmine S, George S, Gunasekaran K, Nanda R, and Bansal V had an equal role in data collection, analysis; Peter JV helped in further revisions of the manuscript; and supported the writing of the manuscript equally.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Christian Medical College Vellore, approval No. 2407170.
Informed consent statement: As the corresponding author of the above study, I hereby submit that the consent for this study was waived as per institutional policy for a retrospective study with de-identified patient data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Corresponding author(s) agreed with the data sharing policy.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: John V Peter, Department of Medical Intensive Care, Christian Medical College Vellore, Ida Scudder Road, Vellore 632004, Tamil Nadu, India.
Received: April 21, 2025
Revised: May 19, 2025
Accepted: August 13, 2025
Published online: December 9, 2025
Processing time: 221 Days and 9.9 Hours
Revised: May 19, 2025
Accepted: August 13, 2025
Published online: December 9, 2025
Processing time: 221 Days and 9.9 Hours
Core Tip
Core Tip: In this retrospective single-center study conducted in a medical intensive care unit (ICU) at a tertiary care teaching hospital in India, patients with systemic lupus erythematosus (SLE) and admitted to the ICU were noted to have a high mortality rate despite initiating multi-modal therapy. Respiratory failure and shock were the major reasons for ICU admissions in SLE. The differentiation between SLE flare and infection can be challenging and is the key to effective treatment.