Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Dec 9, 2025; 14(4): 108652
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.108652
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.108652
Clinical and cost-effectiveness of noninvasive ventilation over invasive ventilation in acute respiratory failure: A single-center study from India
Kanwalpreet Sodhi, Harmanpreet Kaur, Tanupriya Sood, Ditya Ditya, Anshul Singla, Department of Critical Care, Deep Hospital, Ludhiana 141002, Punjab, India
Manender Kumar, Department of Cardiac Anaesthesia and Critical Care, Fortis Hospital, Ludhiana 141001, Punjab, India
Sartaaj Tuli, Christian Medical College, Ludhiana 141002, Punjab, India
Ishrat Singla, Armed Forces Medical College, Pune 411040, Maharashtra, India
Author contributions: Sodhi K and Kaur H drafted the initial manuscript; Sodhi K, Kaur H, Sood T, Ditya D, and Singla A participated in the acquisition, analysis, and interpretation of the data; Sodhi K, Kumar M, and Singla I designed the research study; Sood T, Kumar M, Tuli S, and Singla I revised the article critically for important intellectual content; all authors have read and approved the final manuscript.
Institutional review board statement: Obtained the ethics clearance from the institutional ethics committee vide letter, No. ECR/525/Inst/Pb/2014/RR-26/2023-3.
Informed consent statement: Being an observational study, the informed consent from the patients was waved off.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: We agree to share our data.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kanwalpreet Sodhi, MD, Director, Head, Department of Critical Care, Deep Hospital, Model Town, Ludhiana 141002, Punjab, India. drkanwal2006@yahoo.com
Received: April 21, 2025
Revised: May 28, 2025
Accepted: August 12, 2025
Published online: December 9, 2025
Processing time: 223 Days and 5.3 Hours
Revised: May 28, 2025
Accepted: August 12, 2025
Published online: December 9, 2025
Processing time: 223 Days and 5.3 Hours
Core Tip
Core Tip: Mechanical ventilation being a major driver of the intensive care unit (ICU) costs, ventilation costs always need to be taken into account while measuring the financial burden of ICU settings. This is the first large prospective study making head-to-head cost comparison of the invasive and noninvasive ventilation (NIV) modalities in patients with acute respiratory failure. The net average cost of ICU stay was five times lower with NIV. There is an urgent need for further robust research to look into the economic aspects of NIV in comparison to invasive ventilation.