Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Dec 9, 2025; 14(4): 103708
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.103708
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.103708
Length of stay, duration of mechanical ventilation, mortality, and acute kidney injury in acute respiratory failure requiring endotracheal intubation
Panagiotis Papamichalis, Katerina G Oikonomou, Maria Xanthoudaki, Antonios Papadogoulas, Periklis Katsiafylloudis, Evangelia Papapostolou, Achilleas Chovas, Intensive Care Unit, General Hospital of Larissa, Larissa 41221, Thessaly, Greece
Sophia K Papathanasiou, Dimitrios Plageras, Gkreta Mavrommati, Department of Internal Medicine, General Hospital of Larissa, Larissa 41221, Thessaly, Greece
Apostolia Lemonia Skoura, Department of Transfusion Medicine, University Hospital of Larissa, Larissa 41110, Thessaly, Greece
Asimina Valsamaki, Konstantinos Mantzarlis, Department of Critical Care, University Hospital of Larissa, Larissa 41110, Thessaly, Greece
Michail Papamichalis, Department of Cardiology, University Hospital of Larissa, Larissa 41110, Thessaly, Greece
Athanasios Koukoulis, Faculty of Medicine, University of Thessaly, Larissa 41500, Thessaly, Greece
Panagiotis Giannakos, Department of Cardiology, General Hospital of Larissa, Larissa 41221, Thessaly, Greece
Author contributions: Papamichalis P, Oikonomou KG, Xanthoudaki M, and Papathanasiou SK designed the article; Papadogoulas A, Valsamaki A, Skoura AL, Katsiafylloudis P, Papapostolou E, Plageras D, Koukoulis A, Mavrommati G, Giannakos P, and Mantzarlis K assisted in data gathering; Papamichalis P, Oikonomou KG, Xanthoudaki M, and Papathanasiou SK wrote the final version of the manuscript; Oikonomou KG performed English editing; Chovas A critically reviewed the paper; all authors approved the final version to publish.
Institutional review board statement: The study was approved by the institutional review board of General Hospital of Larissa, No. 4851.
Informed consent statement: Due to the retrospective nature of the study and in accordance with the Institutional review board statement, informed consent statement was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Data that support the findings of this study will be available upon request at the e-mail address of the corresponding author for research purposes.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Panagiotis Papamichalis, MD, PhD, Intensive Care Unit, General Hospital of Larissa, 1 Tsakalof, Larissa 41221, Thessaly, Greece. ppapamih@med.uth.gr
Received: November 29, 2024
Revised: April 28, 2025
Accepted: July 7, 2025
Published online: December 9, 2025
Processing time: 365 Days and 5.2 Hours
Revised: April 28, 2025
Accepted: July 7, 2025
Published online: December 9, 2025
Processing time: 365 Days and 5.2 Hours
Core Tip
Core Tip: Identifying prognostic factors in patients with acute respiratory failure requiring invasive mechanical/positive pressure ventilation remains a challenge to date. In the present study, the relationships of the epidemiological, respiratory, and arterial blood gas parameters to the four outcome measures of mortality, development of acute kidney injury, length of stay, and the duration of mechanical ventilation were evaluated. It was revealed that epidemiological factors such as the coronavirus disease 2019 presence and the respiratory parameters peak airway pressure and respiratory rate (RR) affected all the studied outcome measures. The possibility of improving outcomes by reducing the peak airway pressure and the RR and the observed association between RR and acute kidney injury needs further evaluation in future studies.