Urological footprint of chronic kidney disease: A nephrologist perspective on early detection and collaborative management

Abstract

Chronic kidney disease (CKD) is a multifactorial condition in which urological comorbidities including recurrent urinary tract infections, obstructive uropathy, nephrolithiasis, and voiding dysfunction play a critical but often overlooked role in disease onset and progression. This mini-review aims to highlight the prevalence, clinical relevance, and impact of urological disorders in CKD, advocating for their systematic recognition and management within nephrology practice. A narrative synthesis of published literature was conducted, focusing on epidemiological data, clinical studies, and expert consensus addressing the intersection of CKD and urological comorbidities. Evidence indicates that urological disorders are common among CKD patients, particularly in the presence of diabetes mellitus, hypertension, and persistent proteinuria. These conditions accelerate renal decline, increase complications, and impair quality of life. Early detection and timely intervention, coupled with interdisciplinary collaboration between nephrologists and urologists, can delay disease progression and optimize patient outcomes. Integrating urological insights into nephrology care is essential to address the multifactorial nature of CKD. Routine screening for urological comorbidities, proactive management strategies, and closer interdisciplinary collaboration is recommended. Future research should quantify the benefits of such integrative approaches and explore innovative models of care to improve long-term outcomes.

Keywords: Benign prostatic hyperplasia; Chronic kidney disease; Congenital anomalies of the kidney; End-stage kidney disease; Nephrolithiasis; Urological disorders

Core Tip: Chronic kidney disease is increasingly influenced by urological conditions such as recurrent urinary tract infections, obstructive uropathy, and nephrolithiasis are key contributors to chronic kidney disease progression but remain underrecognized in nephrology. To address this gap, nephrologists should embrace a comprehensive care model that actively incorporates urological evaluation, timely referrals, and integrated treatment planning. Enhancing collaboration between nephrology and urology is crucial for reducing kidney complications and delivering truly patient-centered care.