Microbiota decolonization of bacterial pathogens in pediatric surgery-related intestinal disorders: Insights on current strategies and future outlook

Table 1 Current decolonization therapies in pediatric surgical disorders

Therapy	Description	Advantages	Pediatric surgical disorders	Ref.
Selective digestive decontamination	Administration of non-absorbable antibiotics to reduce harmful bacteria load in the gut before surgery	Prevents postoperative infections; Reduces translocation of harmful pathogens	IBD; SBS	[98,159]
Probiotics	Combination pf beneficial bacteria and nutrients that promote their growth	Enhance colonization resistance; Reduces MDR bacteria like Acinetobacter baumannii	IBD; NEC; HAEC; SBS	[105,119-122,139,155]
FMT	Transfer of fecal material from a healthy donor to restore fecal balance	Restores microbial diversity; Suppresses MDR bacteria. Effective for Clostridium dif. infections	IBD; NEC; SBS	[112,126,156,157]

IBD: Inflammatory bowel disease; SBS: Small bowel syndrome; NEC: Necrotizingenterocolitis; HAEC: Hirschsprung-associated enterocolitis; FMT: Fecal microbiota transplantation; MDR: Multi-drug resistance.