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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Dec 9, 2025; 14(4): 107722
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.107722
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.107722
Microbiota decolonization of bacterial pathogens in pediatric surgery-related intestinal disorders: Insights on current strategies and future outlook
Natalia Vaou, Georgia Vrioni, Athanasios Tsakris, Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece
Nikolaos Zavras, George Vaos, Department of Pediatric Surgery, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece
Smaragdi Fessatou, 3rd Department of Pediatrics, Attikon University General Hospital, Medical School, National and Kapodistrian University of Athens, Athens 12462, Greece
Chrysoula Chrysa Voidarou, Department of Agriculture, School of Agriculture, University of Ioannina, Arta 47100, Greece
Co-corresponding authors: Natalia Vaou and Nikolaos Zavras.
Author contributions: Vaou N and Zavras N contributed equally to the conceptualization, design, writing-original draft preparation, writing-review and editing of the manuscript; Fessatou S performed the literature search and analyzed the data; Voidarou C, Vrioni G, and Tsakris A have significantly contributed to the writing of the manuscript by providing supervision and intellectual input; Vaos G supervised the writing of the original draft and critically revised and edited the manuscript. All authors have read and agreed to the published version of the manuscript. Our research consists of two main topics. The role of microbiota decolonization of bacterial pathogens and its impact on treating intestinal disorders affecting infants and children. Therefore, the collaboration of researchers involved in the research of microbiota decolonization and pediatric surgical intestinal disorders were necessary. Vaou N as a Research Fellow in Microbiology (Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece) and Zavras N as Professor of Pediatric Surgery (Emeritus Professor, Department of Pediatric Surgery, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece) substantially participated in the completion of the manuscript. They equally contributed to the conceptualization, design, writing-original draft preparation, writing-review, and editing of the manuscript. Therefore, they should be considered co-corresponding authors, as they have made significant contributions by guiding the study at all stages of its progress.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Natalia Vaou, BSc (Hons)-UK, BSc, MSc, PhDc, Research Fellow, Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 75 M. Asias, Athens 11527, Greece. nvaou@hotmail.com
Received: March 28, 2025
Revised: April 29, 2025
Accepted: August 1, 2025
Published online: December 9, 2025
Processing time: 217 Days and 19.8 Hours
Revised: April 29, 2025
Accepted: August 1, 2025
Published online: December 9, 2025
Processing time: 217 Days and 19.8 Hours
Core Tip
Core Tip: Optimizing gut microbiota composition is a promising strategy for decolonizing bacterial pathogens in pediatric surgery-related intestinal disorders. The decolonization of bacterial pathogens in this condition is crucial for reducing com