©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
World J Clin Pediatr. Mar 9, 2026; 15(1): 115780
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.115780
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.115780
Role of plasma D-dimer levels as diagnostic and prognostic marker in neonatal sepsis: An insightful support
Alessandro Boscarelli, Department of Pediatric Surgery and Urology, Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Trieste 34137, Italy
Author contributions: Boscarelli A is fully accountable for conceiving, writing the initial draft, reviewing, and editing.
Conflict-of-interest statement: The author declares that he has no conflict of interest to disclose.
Corresponding author: Alessandro Boscarelli, MD, Department of Pediatric Surgery and Urology, Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Via Dell'Istria, 65/1, Trieste 34137, Italy. alessandro.boscarelli@burlo.trieste.it
Received: October 25, 2025
Revised: November 6, 2025
Accepted: December 4, 2025
Published online: March 9, 2026
Processing time: 132 Days and 17.9 Hours
Revised: November 6, 2025
Accepted: December 4, 2025
Published online: March 9, 2026
Processing time: 132 Days and 17.9 Hours
Core Tip
Core Tip: Despite advances in neonatal care, sepsis remains a serious health problem with significant morbidity and mortality. Clinical diagnosis at presentation is often challenging due to nonspecific signs and symptoms. Laboratory biomarkers, blood cultures, and other diagnostic/prognostic tools are not considered reliable for routine clinical use. Basiouny et al conducted a two-center prospective case-control study investigating the diagnostic and prognostic utility of D-dimer and heparin-binding protein in neonatal sepsis. While future multicenter studies with larger patient populations are required, these findings indicate the utility of D-dimer inclusion in sepsis diagnostic models.