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Qureshi MA, Sood M, Thakur P, Sood I. Maternal and neonatal determinants of newborn sepsis: A case-control study in resource-limited settings. World J Clin Pediatr 2026; 15(1): 111423 [PMID: 41884033 DOI: 10.5409/wjcp.v15.i1.111423]
World J Clin Pediatr. Mar 9, 2026; 15(1): 111423 Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.111423
Maternal and neonatal determinants of newborn sepsis: A case-control study in resource-limited settings
Mohd Asif Qureshi, Mangla Sood, Pratima Thakur, Ishaan Sood
Mohd Asif Qureshi, Mangla Sood, Pratima Thakur, Ishaan Sood, Department of Pediatrics, Indira Gandhi Medical College, Shimla 171001, Himachal Pradesh, India
Co-first authors: Mohd Asif Qureshi and Mangla Sood.
Author contributions: Sood M designed the study, supervised the study, and drafted the initial manuscript; Qureshi MA, Thakur P and Sood I helped in data collection, and analysis; all authors revised the manuscript critically for important intellectual content and gave final approval before submitting for publication.
Institutional review board statement: The study was reviewed and approved by the IGMC institutional review board.
Informed consent statement: Prior informed written consent was taken from participants legal guardian before enrollment into the study.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement- checklist of items.
Data sharing statement: Dataset available from the corresponding author at drmanglasood@gmail.com.
Corresponding author: Mangla Sood, MD, Professor, Department of Pediatrics, Indira Gandhi Medical College, Shimla Himachal Pradesh, Shimla 171001, Himachal Pradesh, India. drmanglasood@gmail.com
Received: July 1, 2025 Revised: July 9, 2025 Accepted: October 21, 2025 Published online: March 9, 2026 Processing time: 250 Days and 13.9 Hours
Core Tip
Core Tip: Neonatal sepsis in our study was strongly associated with several modifiable maternal and intrapartum factors, namely insufficient antenatal visits, prolonged labor or membrane rupture, forceps delivery, non-sterile vaginal examinations, and maternal urinary tract infections. Compounded by neonatal vulnerabilities including prematurity, very low birth weight, small-for-gestational-age, birth asphyxia, advanced respiratory support need, prolonged newborn intensive care unit (NICU) stays, with the latter reflecting greater exposure to nosocomial pathogens. Targeted, tiered interventions spanning antenatal care through delivery and the NICU, emphasizing risk stratification, aseptic practices, early surveillance, and timely prophylaxis can sharply reduce sepsis rates and enhance newborn survival.
