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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Dec 9, 2025; 14(4): 108920
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.108920
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.108920
Giant coronary aneurysms in children with Kawasaki disease and major cardiac complications and dynamic follow-up
Liudmila V Bregel, Olesya S Efremova, Department of Pediatric Cardiology, Irkutsk Regional Children’s Clinical Hospital, Irkutsk 664022, Russia
Liudmila V Bregel, Olesya S Efremova, Department of Pediatry, Irkutsk State Medical Academy of Postgraduate Education, A Branch of the Russian Medical Academy of Continuous Pro
Vladimir A Podkamenny, Department of Cardiovascular Surgery and Angiology, Irkutsk State Medical Academy of Postgraduate Education, A Branch of the Russian Medical Academy of Continuous Professional Education, Irkutsk 664049, Russia
Vladimir A Podkamenny, Department of Cardiosurgery, Irkutsk Regional Hospital, Irkutsk 664079, Russia
Yurii A Kozlov, Department of General Surgery, Irkutsk State Regional Children's Clinical Hospital, Irkutsk 664022, Russia
Yurii A Kozlov, Department of Pediatrics and Pediatric Surgery, Irkutsk State Medical Uni
Yurii A Kozlov, Department of Pediatric Surgery, Irkutsk State Medical Academy of Post
Mikhail M Kostik, Hospital Pediatry, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Sankt-Peterburg, Russia
Author contributions: Bregel LV and Efremova OS contributed equally to this article; Bregel LV, Efremova OS, and Podkamenny VA contributed to validation; Bregel LV, Efremova OS, and Kostik MM contributed to conceptualization, writing review, editing, writing the original draft, funding, supervision, and project administration; Efremova OS and Podkamenny VA contributed to software, resources, and data curation; Efremova OS and Kostik MM contributed to formal analysis; Podkamenny VA and Kozlov YA contributed to investigation and visualization; Kozlov YA and Kostik MM contributed to the methodology; All authors read and agreed to the published version of the manuscript.
Institutional review board statement: The research paper was reviewed and approved by the Ethics Committee of Irkutsk Regional Children’s Hospital.
Informed consent statement: Informed consent was obtained from all legal representatives of patients to participate in the study, process its results, and publish materials.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mikhail M Kostik, MD, PhD, Professor, Hospital Pediatry, Saint Petersburg State Pediatric Medical University, Lytovskaya 2, Saint Petersburg 194100, Sankt-Peterburg, Russia. kost-mikhail@yandex.ru
Received: April 28, 2025
Revised: May 25, 2025
Accepted: August 12, 2025
Published online: December 9, 2025
Processing time: 187 Days and 9.9 Hours
Revised: May 25, 2025
Accepted: August 12, 2025
Published online: December 9, 2025
Processing time: 187 Days and 9.9 Hours
Core Tip
Core Tip: A study of the evolution of giant and medium-sized coronary aneurysms in children with Kawasaki disease was conducted. Giant coronary aneurysms occurred in 6.5% of patients with Kawasaki disease, and 75.0% of patients with giant/medium coronary aneurysms were male. Only males had giant bilateral coronary aneurysms. Major cardiac events occurred in 38.5% of patients with giant/medium coronary aneurysms. Slow regression of giant/medium-sized coronary aneurysms occurred in all patients, complete regression occurred in 58.0%, and partial regression in 42.0% after an average of 2-4 months (from 1 year to 5 years) of observations with antithrombotic treatment. There were no fatal outcomes.