Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling

doi:10.5312/wjo.v17.i4.116046

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Apr 18, 2026 (publication date) through Apr 16, 2026

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. Apr 18, 2026; 17(4): 116046
Published online Apr 18, 2026. doi: 10.5312/wjo.v17.i4.116046

Table 1 Primer sequences used in quantitative polymerase chain reaction experiments

Target gene	Primer
GAPDH	Forward	AAGATGGTGAAGGTCGGTGT
GAPDH	Reverse	GCTTCCCATTCTCAGCCTTG
Wnt3a	Forward	CTCCTCTCGGATACCTCTTAGTG
Wnt3a	Reverse	GCATGATCTCCACGTAGTTCCTG
β-catenin	Forward	CTTCCAGACACGCCATCATG
β-catenin	Reverse	AAGGTTGTGTAGGGTCCCAG
RUNX2	Forward	CGCCACCACTCACTACCACAC
RUNX2	Reverse	ATAGGACGCTGACGAAGTACCA
GSK3β	Forward	GAGCCACCGATTACACGTC
GSK3β	Reverse	TATTTCCACCAACTGATCCACAC
β-actin	Forward	CTGAACGTGAAATTGTCCGAGA
β-actin	Reverse	TTGCCAATGGTGATGACCTG
RANK	Forward	GCCAGCAAGAAGTGTGTGAA
RANK	Reverse	TCGCTGACTAAGGTGAACGT
RANKL	Forward	CACACGAGGGTCCGCTGCATC
RANKL	Reverse	TGCAGACCACCTGACCCAGTCC
OPG	Forward	ACATCATTGAATGGACAACCCAG
OPG	Reverse	TGCCAGGAGCACATTTGTCA

GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; Wnt3a: Wingless-type MMTV integration site family, member 3A; RUNX2: Runt-related transcription factor 2; GSK3β: Glycogen synthase kinase-3 beta; RANK: Receptor activator of nuclear factor-kappaB; RANKL: Receptor activator of nuclear factor-kappaB ligand; OPG: Osteoprotegerin.

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Citation: Yu AX, Liang WH, Zhou YS, Li P, Ji JM, Zhang FW, Yu P, Liu J. Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling. World J Orthop 2026; 17(4): 116046
URL: https://www.wjgnet.com/2218-5836/full/v17/i4/116046.htm
DOI: https://dx.doi.org/10.5312/wjo.v17.i4.116046