Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling
Ao-Xue Yu, Wei-Hui Liang, Ya-Shuang Zhou, Pan Li, Jia-Mei Ji, Feng-Wei Zhang, Peng Yu, Jia Liu
Ao-Xue Yu, Wei-Hui Liang, Ya-Shuang Zhou, Pan Li, Jia-Mei Ji, Feng-Wei Zhang, Peng Yu, School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China
Jia Liu, Office of Scientific Research, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China
Co-first authors: Ao-Xue Yu and Wei-Hui Liang.
Co-corresponding authors: Peng Yu and Jia Liu.
Author contributions: Yu AX and Liang WH contributed to software, resources, and they contributed equally to this manuscript and are co-first authors; Yu AX, Liang WH, Zhou YS, Li P, Ji JM, and Zhang FW performed the investigation, participated in data curation and validation; Zhou YS was responsible for formal analysis and visualization; Yu P and Liu J participated in conceptualization, funding acquisition, methodology, project administration, supervision, additionally reviewed and edited the manuscript, they contributed equally to this manuscript and are co-corresponding authors. All authors participated in writing the original draft.
Supported by the Science and Technology Department of Jilin Province - Jilin Provincial Science and Technology Development Plan Project, No. 20250204060YY.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Changchun University of Chinese Medicine (Approval No. 2023559).
Conflict-of-interest statement: Liu J reports grant from the Science and Technology Department of Jilin Province, during the conduct of the study. Additionally, all authors have declared that there are no relevant conflicts of interest in this manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The authors have no conflicts of interest to declare.
Corresponding author: Jia Liu, PhD, Office of Scientific Research, Changchun University of Chinese Medicine, No. 1035 Boshuo Road, Jingyue National High-tech Industrial Development Zone, Changchun 130117, Jilin Province, China.
ccliujia1002@126.com
Received: November 3, 2025
Revised: November 17, 2025
Accepted: January 9, 2026
Published online: April 18, 2026
Processing time: 160 Days and 18.7 Hours
