Jeyaraman M, Jeyaraman N, Jayakumar T, Ramasubramanian S, Ranjan R, Jha SK, Gupta A. Efficacy of stromal vascular fraction for knee osteoarthritis: A prospective, single-centre, non-randomized study with 2 years follow-up. World J Orthop 2024; 15(5): 457-468 [PMID: 38835682 DOI: 10.5312/wjo.v15.i5.457]
Corresponding Author of This Article
Madhan Jeyaraman, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu 600077, India. madhanjeyaraman@gmail.com
Research Domain of This Article
Cell & Tissue Engineering
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
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World J Orthop. May 18, 2024; 15(5): 457-468 Published online May 18, 2024. doi: 10.5312/wjo.v15.i5.457
Table 1 Demographic characteristics of the study population, n (%)
Parameters
Group A (n = 25)
Group B (n = 25)
P value
Age (yr)
0.95
31–40
3 (12)
4 (16)
41–50
6 (24)
5 (20)
51–60
7 (28)
8 (32)
61–70
9 (36)
8 (32)
Sex
0.57
Male
12 (48)
14 (56)
Female
13 (52)
11 (44)
BMI
0.94
18.5-24.9
9 (36)
9 (36)
25.0-29.9
8 (32)
9 (36)
30.0-35.0
8 (32)
7 (28)
K-L grading
0.58
II
11 (44)
13 (52)
III
14 (56)
12 (48)
Table 2 Visual analog score in various time-points
Time-point
Group A (n = 23)
Group B (n = 24)
Standard error
95%CI
t
P value
Pre-procedure
7.7 ± 1.1
7.8 ± 0.8
0.272
-0.44-0.64
0.37
0.71
1 month Follow-up
7.0 ± 1.8
7.2 ± 1.0
0.41
-0.62-1.02
0.48
0.561
3 months Follow-up
6.5 ± 1.8
7.6 ± 1.6
0.48
0.13-2.06
2.28
0.03
6 months Follow-up
4.3 ± 1.4
6.8 ± 1.2
0.36
1.75-3.24
6.78
< 0.001
12 months Follow-up
2.3 ± 0.20
6.1 ± 0.80
0.16
3.47-4.13
23.04
< 0.001
24 months Follow-up
2.4 ± 0.88
6.2 ± 1.1
0.27
3.25-4.34
13.97
< 0.001
Table 3 International Knee Documentation Committee score in various time-points
Time-point
Group A (n = 23)
Group B (n = 24)
Standard error
95%CI
t
P value
Pre-procedure
33.4 ± 10.20
36.7 ± 9.17
2.743
-2.22-8.82
1.20
0.23
1 month Follow-up
58.14 ± 17.23
56.6 ± 18.25
5.02
-11.63-8.55
-0.307
0.76
3 months Follow-up
60.3 ± 14.21
54.2 ± 13.25
3.88
-13.91-1.71
-1.57
0.12
6 months Follow-up
62.6 ± 13.27
50.16 ± 12.35
3.62
-19.72 to -5.15
-3.431
0.001
12 months Follow-up
78.3 ± 12.24
48.76 ± 12.17
3.45
-36.48 to -22.59
-8.56
< 0.001
24 months Follow-up
83.10 ± 18.25
45.16 ± 12.35
4.40
-46.80 to -29.07
-8.61
< 0.001
Table 4 Magnetic resonance observation of cartilage repair tissue 2.0 knee score at baseline and 24-month follow-up
Time-point
Group A (n = 23)
Group B (n = 24)
Standard error
95%CI
t
P value
Baseline
52.7 ± 6.2
53.3 ± 4.7
1.60
-2.62-3.82
0.37
0.71
24 months follow-up
91.8 ± 5.1
61.2 ± 8.4
2.03
-34.70 to -26.49
-15.01
< 0.001
Citation: Jeyaraman M, Jeyaraman N, Jayakumar T, Ramasubramanian S, Ranjan R, Jha SK, Gupta A. Efficacy of stromal vascular fraction for knee osteoarthritis: A prospective, single-centre, non-randomized study with 2 years follow-up. World J Orthop 2024; 15(5): 457-468